PCNP protein (Homo sapiens) - STRING network view

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PCNP

PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation (178 aa)

Predicted Functional Partners:

UHRF2

0.920

UBC

0.765

NPDC1

0.542

ENSG00000267022

0.499

ZNF223

0.499

PSPH

0.433

CA7

0.426

NPR2

0.423

NPR3

0.416

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CA7	PCNP	ENSP00000345659	ENSP00000265260	carbonic anhydrase VII; Reversible hydration of carbon dioxide	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	0.426
ENSG00000267022	PCNP	ENSP00000467018	ENSP00000265260	Kruppel-associated box ; May be involved in transcriptional regulation	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	0.499
NPDC1	PCNP	ENSP00000360660	ENSP00000265260	neural proliferation, differentiation and control, 1; Suppresses oncogenic transformation in neural and non- neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity)	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	0.542
NPDC1	UBC	ENSP00000360660	ENSP00000344818	neural proliferation, differentiation and control, 1; Suppresses oncogenic transformation in neural and non- neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity)	ubiquitin C	0.912
NPR2	PCNP	ENSP00000341083	ENSP00000265260	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	0.423
NPR2	UBC	ENSP00000341083	ENSP00000344818	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	ubiquitin C	0.518
NPR3	PCNP	ENSP00000265074	ENSP00000265260	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	0.416
NPR3	UBC	ENSP00000265074	ENSP00000344818	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity	ubiquitin C	0.533
PCNP	CA7	ENSP00000265260	ENSP00000345659	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	carbonic anhydrase VII; Reversible hydration of carbon dioxide	0.426
PCNP	ENSG00000267022	ENSP00000265260	ENSP00000467018	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	Kruppel-associated box ; May be involved in transcriptional regulation	0.499
PCNP	NPDC1	ENSP00000265260	ENSP00000360660	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	neural proliferation, differentiation and control, 1; Suppresses oncogenic transformation in neural and non- neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity)	0.542
PCNP	NPR2	ENSP00000265260	ENSP00000341083	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	0.423
PCNP	NPR3	ENSP00000265260	ENSP00000265074	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity	0.416
PCNP	PSPH	ENSP00000265260	ENSP00000275605	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates	0.433
PCNP	UBC	ENSP00000265260	ENSP00000344818	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	ubiquitin C	0.765
PCNP	UHRF2	ENSP00000265260	ENSP00000276893	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Appears to contribute to tumorigenesis	0.920
PCNP	ZNF223	ENSP00000265260	ENSP00000401947	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	zinc finger protein 223; May be involved in transcriptional regulation	0.499
PSPH	PCNP	ENSP00000275605	ENSP00000265260	phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates	PEST proteolytic signal containing nuclear protein; May be involved in cell cycle regulation	0.433
PSPH	UBC	ENSP00000275605	ENSP00000344818	phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates	ubiquitin C	0.554
UBC	NPDC1	ENSP00000344818	ENSP00000360660	ubiquitin C	neural proliferation, differentiation and control, 1; Suppresses oncogenic transformation in neural and non- neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity)	0.912

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