node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA2 | ABCB6 | ENSP00000344155 | ENSP00000265316 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | 0.917 |
ABCA2 | ABCB8 | ENSP00000344155 | ENSP00000351717 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATP-binding cassette, sub-family B (MDR/TAP), member 8 | 0.792 |
ABCA2 | ABCD4 | ENSP00000344155 | ENSP00000349396 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATP-binding cassette, sub-family D (ALD), member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm | 0.937 |
ABCA2 | ABCF2 | ENSP00000344155 | ENSP00000222388 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATP-binding cassette, sub-family F (GCN20), member 2 | 0.881 |
ABCA2 | ATP1A3 | ENSP00000344155 | ENSP00000302397 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATPase, Na+/K+ transporting, alpha 3 polypeptide; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients | 0.906 |
ABCA2 | ATP1A4 | ENSP00000344155 | ENSP00000357060 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ATPase, Na+/K+ transporting, alpha 4 polypeptide; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility | 0.906 |
ABCA2 | UBC | ENSP00000344155 | ENSP00000344818 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | ubiquitin C | 0.515 |
ABCB6 | ABCA2 | ENSP00000265316 | ENSP00000344155 | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | 0.917 |
ABCB6 | ABCB8 | ENSP00000265316 | ENSP00000351717 | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | ATP-binding cassette, sub-family B (MDR/TAP), member 8 | 0.821 |
ABCB6 | ABCD4 | ENSP00000265316 | ENSP00000349396 | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | ATP-binding cassette, sub-family D (ALD), member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm | 0.915 |
ABCB6 | ABCF2 | ENSP00000265316 | ENSP00000222388 | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | ATP-binding cassette, sub-family F (GCN20), member 2 | 0.905 |
ABCB6 | AHR | ENSP00000265316 | ENSP00000242057 | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues | 0.810 |
ABCB6 | ATP1A3 | ENSP00000265316 | ENSP00000302397 | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | ATPase, Na+/K+ transporting, alpha 3 polypeptide; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients | 0.902 |
ABCB6 | ATP1A4 | ENSP00000265316 | ENSP00000357060 | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | ATPase, Na+/K+ transporting, alpha 4 polypeptide; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility | 0.902 |
ABCB6 | SLC25A28 | ENSP00000265316 | ENSP00000359526 | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | solute carrier family 25 (mitochondrial iron transporter), member 28; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity) | 0.786 |
ABCB6 | SLC25A37 | ENSP00000265316 | ENSP00000429200 | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | solute carrier family 25 (mitochondrial iron transporter), member 37; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity) | 0.864 |
ABCB6 | UBC | ENSP00000265316 | ENSP00000344818 | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | ubiquitin C | 0.899 |
ABCB8 | ABCA2 | ENSP00000351717 | ENSP00000344155 | ATP-binding cassette, sub-family B (MDR/TAP), member 8 | ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development | 0.792 |
ABCB8 | ABCB6 | ENSP00000351717 | ENSP00000265316 | ATP-binding cassette, sub-family B (MDR/TAP), member 8 | ATP-binding cassette, sub-family B (MDR/TAP), member 6; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | 0.821 |
ABCB8 | ABCD4 | ENSP00000351717 | ENSP00000349396 | ATP-binding cassette, sub-family B (MDR/TAP), member 8 | ATP-binding cassette, sub-family D (ALD), member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm | 0.784 |