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ELK4 ELK4 RPS6KA1 RPS6KA1 RPS6KA3 RPS6KA3 FOS FOS TAGLN TAGLN SRF SRF MKL1 MKL1 GATA4 GATA4 MYOCD MYOCD HOPX HOPX NKX2-5 NKX2-5
"SRF" - serum response factor (c-fos serum response element-binding transcription factor) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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SRFserum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation (508 aa)    
Predicted Functional Partners:
MYOCD
myocardin; Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity) (986 aa)
        score_image score_image score_image   0.999
MKL1
megakaryoblastic leukemia (translocation) 1; Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity) (931 aa)
        score_image score_image score_image   0.999
ELK4
ELK4, ETS-domain protein (SRF accessory protein 1); Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at ’Lys-18’ (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5’side of SRF, but does not bind DNA autonomously (431 aa)
        score_image score_image score_image   0.998
FOS
FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell p [...] (380 aa)
        score_image score_image score_image   0.998
NKX2-5
NK2 homeobox 5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity) (324 aa)
        score_image score_image score_image   0.997
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1 (744 aa)
        score_image score_image score_image   0.995
GATA4
GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (442 aa)
        score_image score_image score_image   0.994
TAGLN
transgelin; Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence (201 aa)
          score_image score_image   0.993
HOPX
HOP homeobox; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor (112 aa)
        score_image score_image score_image   0.993
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at ’Ser-10’, which results [...] (740 aa)
        score_image score_image score_image   0.990
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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