node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL6A5 | ENSG00000259753 | ENSP00000265379 | ENSP00000456711 | collagen, type VI, alpha 5 | Integrin beta | 0.809 |
COL6A5 | ITGA5 | ENSP00000265379 | ENSP00000293379 | collagen, type VI, alpha 5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions | 0.820 |
COL6A5 | ITGA7 | ENSP00000265379 | ENSP00000452120 | collagen, type VI, alpha 5 | integrin, alpha 7 | 0.834 |
COL6A5 | ITGB1 | ENSP00000265379 | ENSP00000303351 | collagen, type VI, alpha 5 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.814 |
COL6A5 | ITGB4 | ENSP00000265379 | ENSP00000200181 | collagen, type VI, alpha 5 | integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility | 0.809 |
COL6A5 | ITGB5 | ENSP00000265379 | ENSP00000296181 | collagen, type VI, alpha 5 | integrin, beta 5; Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand | 0.809 |
COL6A5 | ITGB6 | ENSP00000265379 | ENSP00000283249 | collagen, type VI, alpha 5 | integrin, beta 6; Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion | 0.809 |
COL6A5 | ITGB7 | ENSP00000265379 | ENSP00000267082 | collagen, type VI, alpha 5 | integrin, beta 7; Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in M [...] | 0.809 |
COL6A5 | ITGB8 | ENSP00000265379 | ENSP00000222573 | collagen, type VI, alpha 5 | integrin, beta 8; Integrin alpha-V/beta-8 is a receptor for fibronectin | 0.809 |
COL6A5 | PTK2 | ENSP00000265379 | ENSP00000341189 | collagen, type VI, alpha 5 | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.826 |
ENSG00000259753 | COL6A5 | ENSP00000456711 | ENSP00000265379 | Integrin beta | collagen, type VI, alpha 5 | 0.809 |
ENSG00000259753 | ITGA5 | ENSP00000456711 | ENSP00000293379 | Integrin beta | integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions | 0.965 |
ENSG00000259753 | ITGA7 | ENSP00000456711 | ENSP00000452120 | Integrin beta | integrin, alpha 7 | 0.931 |
ENSG00000259753 | PTK2 | ENSP00000456711 | ENSP00000341189 | Integrin beta | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.858 |
ITGA5 | COL6A5 | ENSP00000293379 | ENSP00000265379 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions | collagen, type VI, alpha 5 | 0.820 |
ITGA5 | ENSG00000259753 | ENSP00000293379 | ENSP00000456711 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions | Integrin beta | 0.965 |
ITGA5 | ITGA7 | ENSP00000293379 | ENSP00000452120 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions | integrin, alpha 7 | 0.835 |
ITGA5 | ITGB1 | ENSP00000293379 | ENSP00000303351 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.999 |
ITGA5 | ITGB4 | ENSP00000293379 | ENSP00000200181 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions | integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility | 0.957 |
ITGA5 | ITGB5 | ENSP00000293379 | ENSP00000296181 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions | integrin, beta 5; Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand | 0.990 |