node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NPL2 | PI4KA | ENSP00000359683 | ENSP00000458238 | Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein | phosphatidylinositol 4-kinase, catalytic, alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate | 0.825 |
NPL2 | PIP5K1B | ENSP00000359683 | ENSP00000265382 | Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.931 |
NPL2 | PLCB1 | ENSP00000359683 | ENSP00000338185 | Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein | phospholipase C, beta 1 (phosphoinositide-specific) | 0.905 |
NPL2 | PLCB4 | ENSP00000359683 | ENSP00000334105 | Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein | phospholipase C, beta 4 | 0.905 |
NPL2 | PLCD1 | ENSP00000359683 | ENSP00000430344 | Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein | phospholipase C, delta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development | 0.905 |
NPL2 | PTEN | ENSP00000359683 | ENSP00000361021 | Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein | phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.904 |
NPL2 | SYNJ1 | ENSP00000359683 | ENSP00000409667 | Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein | synaptojanin 1; Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis | 0.915 |
NPL2 | SYNJ2 | ENSP00000359683 | ENSP00000347792 | Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein | synaptojanin 2; Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis | 0.915 |
PI4K2A | PI4KA | ENSP00000359665 | ENSP00000458238 | phosphatidylinositol 4-kinase type 2 alpha; Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity) | phosphatidylinositol 4-kinase, catalytic, alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate | 0.809 |
PI4K2A | PIP5K1B | ENSP00000359665 | ENSP00000265382 | phosphatidylinositol 4-kinase type 2 alpha; Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity) | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.931 |
PI4K2A | SYNJ1 | ENSP00000359665 | ENSP00000409667 | phosphatidylinositol 4-kinase type 2 alpha; Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity) | synaptojanin 1; Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis | 0.930 |
PI4K2A | SYNJ2 | ENSP00000359665 | ENSP00000347792 | phosphatidylinositol 4-kinase type 2 alpha; Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity) | synaptojanin 2; Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis | 0.922 |
PI4KA | NPL2 | ENSP00000458238 | ENSP00000359683 | phosphatidylinositol 4-kinase, catalytic, alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate | Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein | 0.825 |
PI4KA | PI4K2A | ENSP00000458238 | ENSP00000359665 | phosphatidylinositol 4-kinase, catalytic, alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate | phosphatidylinositol 4-kinase type 2 alpha; Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity) | 0.809 |
PI4KA | PIP5K1B | ENSP00000458238 | ENSP00000265382 | phosphatidylinositol 4-kinase, catalytic, alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.960 |
PI4KA | PLCB1 | ENSP00000458238 | ENSP00000338185 | phosphatidylinositol 4-kinase, catalytic, alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate | phospholipase C, beta 1 (phosphoinositide-specific) | 0.923 |
PI4KA | PLCB4 | ENSP00000458238 | ENSP00000334105 | phosphatidylinositol 4-kinase, catalytic, alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate | phospholipase C, beta 4 | 0.923 |
PI4KA | PLCD1 | ENSP00000458238 | ENSP00000430344 | phosphatidylinositol 4-kinase, catalytic, alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate | phospholipase C, delta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development | 0.925 |
PI4KA | PTEN | ENSP00000458238 | ENSP00000361021 | phosphatidylinositol 4-kinase, catalytic, alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate | phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.929 |
PI4KA | SYNJ1 | ENSP00000458238 | ENSP00000409667 | phosphatidylinositol 4-kinase, catalytic, alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate | synaptojanin 1; Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis | 0.964 |