| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CTSK | MITF | ENSP00000271651 | ENSP00000295600 | cathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation | microphthalmia-associated transcription factor | 0.896 |
| CTSK | TFE3 | ENSP00000271651 | ENSP00000314129 | cathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation | transcription factor binding to IGHM enhancer 3; Transcription factor that specifically recognizes and binds E-box sequences (5’-CANNTG-3’). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/M [...] | 0.561 |
| CTSK | TFEB | ENSP00000271651 | ENSP00000230323 | cathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation | transcription factor EB; Transcription factor that specifically recognizes and binds E-box sequences (5’-CANNTG-3’). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5’-GTCACGTGAC-3’) present in the regulatory region of many lysosomal genes, leading to activate the [...] | 0.606 |
| CTSK | TFEC | ENSP00000271651 | ENSP00000265440 | cathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation | transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By sim [...] | 0.609 |
| DEFB127 | TFEC | ENSP00000371825 | ENSP00000265440 | defensin, beta 127; Has antibacterial activity (Potential) | transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By sim [...] | 0.612 |
| MITF | CTSK | ENSP00000295600 | ENSP00000271651 | microphthalmia-associated transcription factor | cathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation | 0.896 |
| MITF | PAX2 | ENSP00000295600 | ENSP00000396259 | microphthalmia-associated transcription factor | paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS | 0.943 |
| MITF | PAX5 | ENSP00000295600 | ENSP00000350844 | microphthalmia-associated transcription factor | paired box 5 | 0.677 |
| MITF | PAX8 | ENSP00000295600 | ENSP00000395498 | microphthalmia-associated transcription factor | paired box 8; Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells | 0.679 |
| MITF | PMEL | ENSP00000295600 | ENSP00000402758 | microphthalmia-associated transcription factor | premelanosome protein; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity | 0.966 |
| MITF | TFE3 | ENSP00000295600 | ENSP00000314129 | microphthalmia-associated transcription factor | transcription factor binding to IGHM enhancer 3; Transcription factor that specifically recognizes and binds E-box sequences (5’-CANNTG-3’). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/M [...] | 0.601 |
| MITF | TFEB | ENSP00000295600 | ENSP00000230323 | microphthalmia-associated transcription factor | transcription factor EB; Transcription factor that specifically recognizes and binds E-box sequences (5’-CANNTG-3’). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5’-GTCACGTGAC-3’) present in the regulatory region of many lysosomal genes, leading to activate the [...] | 0.610 |
| MITF | TFEC | ENSP00000295600 | ENSP00000265440 | microphthalmia-associated transcription factor | transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By sim [...] | 0.598 |
| MYB | PAX2 | ENSP00000339992 | ENSP00000396259 | v-myb myeloblastosis viral oncogene homolog (avian) | paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS | 0.896 |
| MYB | PAX5 | ENSP00000339992 | ENSP00000350844 | v-myb myeloblastosis viral oncogene homolog (avian) | paired box 5 | 0.995 |
| MYB | TFEC | ENSP00000339992 | ENSP00000265440 | v-myb myeloblastosis viral oncogene homolog (avian) | transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By sim [...] | 0.907 |
| PAX2 | MITF | ENSP00000396259 | ENSP00000295600 | paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS | microphthalmia-associated transcription factor | 0.943 |
| PAX2 | MYB | ENSP00000396259 | ENSP00000339992 | paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS | v-myb myeloblastosis viral oncogene homolog (avian) | 0.896 |
| PAX2 | TFE3 | ENSP00000396259 | ENSP00000314129 | paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS | transcription factor binding to IGHM enhancer 3; Transcription factor that specifically recognizes and binds E-box sequences (5’-CANNTG-3’). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/M [...] | 0.616 |
| PAX2 | TFEB | ENSP00000396259 | ENSP00000230323 | paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS | transcription factor EB; Transcription factor that specifically recognizes and binds E-box sequences (5’-CANNTG-3’). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5’-GTCACGTGAC-3’) present in the regulatory region of many lysosomal genes, leading to activate the [...] | 0.552 |
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