node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP1 | AKAP13 | ENSP00000337736 | ENSP00000354718 | A kinase (PRKA) anchor protein 1; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane | A kinase (PRKA) anchor protein 13 | 0.720 |
AKAP1 | AKAP5 | ENSP00000337736 | ENSP00000315615 | A kinase (PRKA) anchor protein 1; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane | A kinase (PRKA) anchor protein 5; May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade | 0.745 |
AKAP1 | AKAP8 | ENSP00000337736 | ENSP00000269701 | A kinase (PRKA) anchor protein 1; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane | A kinase (PRKA) anchor protein 8; Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) | 0.754 |
AKAP1 | AKAP9 | ENSP00000337736 | ENSP00000348573 | A kinase (PRKA) anchor protein 1; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane | A kinase (PRKA) anchor protein (yotiao) 9 | 0.705 |
AKAP1 | PRKACA | ENSP00000337736 | ENSP00000309591 | A kinase (PRKA) anchor protein 1; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | 0.943 |
AKAP1 | PRKACB | ENSP00000337736 | ENSP00000359719 | A kinase (PRKA) anchor protein 1; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane | protein kinase, cAMP-dependent, catalytic, beta | 0.974 |
AKAP1 | PRKACG | ENSP00000337736 | ENSP00000366488 | A kinase (PRKA) anchor protein 1; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane | protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus | 0.900 |
AKAP1 | PRKAR2A | ENSP00000337736 | ENSP00000265563 | A kinase (PRKA) anchor protein 1; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.999 |
AKAP1 | RAB32 | ENSP00000337736 | ENSP00000356465 | A kinase (PRKA) anchor protein 1; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane | RAB32, member RAS oncogene family; Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis | 0.436 |
AKAP13 | AKAP1 | ENSP00000354718 | ENSP00000337736 | A kinase (PRKA) anchor protein 13 | A kinase (PRKA) anchor protein 1; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane | 0.720 |
AKAP13 | AKAP5 | ENSP00000354718 | ENSP00000315615 | A kinase (PRKA) anchor protein 13 | A kinase (PRKA) anchor protein 5; May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade | 0.457 |
AKAP13 | AKAP9 | ENSP00000354718 | ENSP00000348573 | A kinase (PRKA) anchor protein 13 | A kinase (PRKA) anchor protein (yotiao) 9 | 0.561 |
AKAP13 | PRKACA | ENSP00000354718 | ENSP00000309591 | A kinase (PRKA) anchor protein 13 | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | 0.605 |
AKAP13 | PRKACB | ENSP00000354718 | ENSP00000359719 | A kinase (PRKA) anchor protein 13 | protein kinase, cAMP-dependent, catalytic, beta | 0.909 |
AKAP13 | PRKACG | ENSP00000354718 | ENSP00000366488 | A kinase (PRKA) anchor protein 13 | protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus | 0.906 |
AKAP13 | PRKAR2A | ENSP00000354718 | ENSP00000265563 | A kinase (PRKA) anchor protein 13 | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.992 |
AKAP5 | AKAP1 | ENSP00000315615 | ENSP00000337736 | A kinase (PRKA) anchor protein 5; May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade | A kinase (PRKA) anchor protein 1; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane | 0.745 |
AKAP5 | AKAP13 | ENSP00000315615 | ENSP00000354718 | A kinase (PRKA) anchor protein 5; May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade | A kinase (PRKA) anchor protein 13 | 0.457 |
AKAP5 | AKAP8 | ENSP00000315615 | ENSP00000269701 | A kinase (PRKA) anchor protein 5; May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade | A kinase (PRKA) anchor protein 8; Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) | 0.744 |
AKAP5 | AKAP9 | ENSP00000315615 | ENSP00000348573 | A kinase (PRKA) anchor protein 5; May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade | A kinase (PRKA) anchor protein (yotiao) 9 | 0.512 |