OPRK1 protein (Homo sapiens) - STRING network view

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OPRK1

opioid receptor, kappa 1; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions (380 aa)

Predicted Functional Partners:

PDYN

0.971

GABARAPL1

0.966

OPRD1

0.957

TAS2R16

0.954

NPB

0.945

PENK

0.944

NPW

0.943

POMC

0.938

PNOC

0.937

CNR1

0.933

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNR1	NPB	ENSP00000358511	ENSP00000332766	cannabinoid receptor 1 (brain)	neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity)	0.900
CNR1	NPW	ENSP00000358511	ENSP00000330070	cannabinoid receptor 1 (brain)	neuropeptide W; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30	0.900
CNR1	OPRD1	ENSP00000358511	ENSP00000234961	cannabinoid receptor 1 (brain)	opioid receptor, delta 1; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins	0.922
CNR1	OPRK1	ENSP00000358511	ENSP00000265572	cannabinoid receptor 1 (brain)	opioid receptor, kappa 1; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions	0.933
CNR1	PDYN	ENSP00000358511	ENSP00000217305	cannabinoid receptor 1 (brain)	prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity)	0.948
CNR1	PENK	ENSP00000358511	ENSP00000324248	cannabinoid receptor 1 (brain)	proenkephalin; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum	0.948
CNR1	PNOC	ENSP00000358511	ENSP00000301908	cannabinoid receptor 1 (brain)	prepronociceptin; Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development (By similarity)	0.907
CNR1	POMC	ENSP00000358511	ENSP00000264708	cannabinoid receptor 1 (brain)	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.954
CNR1	TAS2R16	ENSP00000358511	ENSP00000249284	cannabinoid receptor 1 (brain)	taste receptor, type 2, member 16; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5	0.901
GABARAPL1	OPRK1	ENSP00000266458	ENSP00000265572	GABA(A) receptor-associated protein like 1; Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles	opioid receptor, kappa 1; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions	0.966
NPB	CNR1	ENSP00000332766	ENSP00000358511	neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity)	cannabinoid receptor 1 (brain)	0.900
NPB	NPW	ENSP00000332766	ENSP00000330070	neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity)	neuropeptide W; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30	0.988
NPB	OPRD1	ENSP00000332766	ENSP00000234961	neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity)	opioid receptor, delta 1; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins	0.937
NPB	OPRK1	ENSP00000332766	ENSP00000265572	neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity)	opioid receptor, kappa 1; Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions	0.945
NPB	PDYN	ENSP00000332766	ENSP00000217305	neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity)	prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity)	0.912
NPB	PENK	ENSP00000332766	ENSP00000324248	neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity)	proenkephalin; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum	0.905
NPB	PNOC	ENSP00000332766	ENSP00000301908	neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity)	prepronociceptin; Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development (By similarity)	0.905
NPB	POMC	ENSP00000332766	ENSP00000264708	neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity)	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.916
NPB	TAS2R16	ENSP00000332766	ENSP00000249284	neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway (By similarity)	taste receptor, type 2, member 16; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5	0.900
NPW	CNR1	ENSP00000330070	ENSP00000358511	neuropeptide W; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30	cannabinoid receptor 1 (brain)	0.900

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