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SLC12A5 SLC12A5 SP1 SP1 GABRG2 GABRG2 EFHC1 EFHC1 CLCN2 CLCN2 KCNMB3 KCNMB3 GABRA1 GABRA1 GABRD GABRD GLRB GLRB GABRB3 GABRB3 FGF7 FGF7
"CLCN2" - chloride channel, voltage-sensitive 2 in Homo sapiens
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CLCN2chloride channel, voltage-sensitive 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport (898 aa)    
Predicted Functional Partners:
FGF7
fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (194 aa)
             score_image   0.896
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons (1139 aa)
             score_image   0.858
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (456 aa)
           score_image score_image   0.812
GABRD
gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (452 aa)
           score_image score_image   0.811
EFHC1
EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death (640 aa)
             score_image   0.803
SP1
Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] (785 aa)
             score_image   0.800
GLRB
glycine receptor, beta; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) (497 aa)
           score_image score_image   0.761
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (515 aa)
           score_image score_image   0.760
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not indu [...] (279 aa)
             score_image   0.741
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (473 aa)
           score_image score_image   0.725
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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