node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS2 | NPTX2 | ENSP00000251582 | ENSP00000265634 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | neuronal pentraxin II; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity) | 0.581 |
AVP | HCRTR1 | ENSP00000369647 | ENSP00000362810 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | hypocretin (orexin) receptor 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity) | 0.912 |
AVP | NPTX2 | ENSP00000369647 | ENSP00000265634 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | neuronal pentraxin II; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity) | 0.909 |
AVP | PDYN | ENSP00000369647 | ENSP00000217305 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) | 0.623 |
HCRTR1 | AVP | ENSP00000362810 | ENSP00000369647 | hypocretin (orexin) receptor 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity) | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | 0.912 |
HCRTR1 | NPTX2 | ENSP00000362810 | ENSP00000265634 | hypocretin (orexin) receptor 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity) | neuronal pentraxin II; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity) | 0.487 |
MT-ATP6 | MT-ATP8 | ENSP00000354632 | ENSP00000355265 | mitochondrially encoded ATP synthase 6 | mitochondrially encoded ATP synthase 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | 0.991 |
MT-ATP6 | MT-ND6 | ENSP00000354632 | ENSP00000354665 | mitochondrially encoded ATP synthase 6 | mitochondrially encoded NADH dehydrogenase 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | 0.824 |
MT-ATP6 | NPTX2 | ENSP00000354632 | ENSP00000265634 | mitochondrially encoded ATP synthase 6 | neuronal pentraxin II; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity) | 0.700 |
MT-ATP8 | MT-ATP6 | ENSP00000355265 | ENSP00000354632 | mitochondrially encoded ATP synthase 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | mitochondrially encoded ATP synthase 6 | 0.991 |
MT-ATP8 | MT-ND6 | ENSP00000355265 | ENSP00000354665 | mitochondrially encoded ATP synthase 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | mitochondrially encoded NADH dehydrogenase 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | 0.835 |
MT-ATP8 | NPTX2 | ENSP00000355265 | ENSP00000265634 | mitochondrially encoded ATP synthase 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | neuronal pentraxin II; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity) | 0.658 |
MT-ND6 | MT-ATP6 | ENSP00000354665 | ENSP00000354632 | mitochondrially encoded NADH dehydrogenase 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | mitochondrially encoded ATP synthase 6 | 0.824 |
MT-ND6 | MT-ATP8 | ENSP00000354665 | ENSP00000355265 | mitochondrially encoded NADH dehydrogenase 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | mitochondrially encoded ATP synthase 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | 0.835 |
MT-ND6 | NPTX2 | ENSP00000354665 | ENSP00000265634 | mitochondrially encoded NADH dehydrogenase 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | neuronal pentraxin II; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity) | 0.700 |
NPTX2 | ADAMTS2 | ENSP00000265634 | ENSP00000251582 | neuronal pentraxin II; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity) | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | 0.581 |
NPTX2 | AVP | ENSP00000265634 | ENSP00000369647 | neuronal pentraxin II; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity) | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | 0.909 |
NPTX2 | HCRTR1 | ENSP00000265634 | ENSP00000362810 | neuronal pentraxin II; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity) | hypocretin (orexin) receptor 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity) | 0.487 |
NPTX2 | MT-ATP6 | ENSP00000265634 | ENSP00000354632 | neuronal pentraxin II; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity) | mitochondrially encoded ATP synthase 6 | 0.700 |
NPTX2 | MT-ATP8 | ENSP00000265634 | ENSP00000355265 | neuronal pentraxin II; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity) | mitochondrially encoded ATP synthase 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | 0.658 |