| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABP1 | SH2D4A | ENSP00000354193 | ENSP00000265807 | amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function | SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function | 0.687 |
| AMELY | SH2D4A | ENSP00000215479 | ENSP00000265807 | amelogenin, Y-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel | SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function | 0.598 |
| DBNL | SH2D4A | ENSP00000417653 | ENSP00000265807 | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] | SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function | 0.794 |
| DBNL | SH3GL1 | ENSP00000417653 | ENSP00000269886 | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] | SH3-domain GRB2-like 1; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity) | 0.748 |
| EHD3 | FAM65A | ENSP00000327116 | ENSP00000400099 | EH-domain containing 3; Plays a role in endocytic transport | family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...] | 0.582 |
| EHD3 | PLEKHH1 | ENSP00000327116 | ENSP00000330278 | EH-domain containing 3; Plays a role in endocytic transport | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | 0.405 |
| EHD3 | PLEKHH2 | ENSP00000327116 | ENSP00000282406 | EH-domain containing 3; Plays a role in endocytic transport | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia | 0.739 |
| EHD3 | SH2D4A | ENSP00000327116 | ENSP00000265807 | EH-domain containing 3; Plays a role in endocytic transport | SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function | 0.717 |
| FAM65A | EHD3 | ENSP00000400099 | ENSP00000327116 | family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...] | EH-domain containing 3; Plays a role in endocytic transport | 0.582 |
| FAM65A | PLEKHH1 | ENSP00000400099 | ENSP00000330278 | family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...] | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | 0.489 |
| FAM65A | PLEKHH2 | ENSP00000400099 | ENSP00000282406 | family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...] | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia | 0.597 |
| FAM65A | SH2D4A | ENSP00000400099 | ENSP00000265807 | family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...] | SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function | 0.597 |
| HCLS1 | SH2D4A | ENSP00000320176 | ENSP00000265807 | hematopoietic cell-specific Lyn substrate 1; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression | SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function | 0.715 |
| PLEKHH1 | EHD3 | ENSP00000330278 | ENSP00000327116 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | EH-domain containing 3; Plays a role in endocytic transport | 0.405 |
| PLEKHH1 | FAM65A | ENSP00000330278 | ENSP00000400099 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...] | 0.489 |
| PLEKHH1 | SH2D4A | ENSP00000330278 | ENSP00000265807 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function | 0.596 |
| PLEKHH2 | EHD3 | ENSP00000282406 | ENSP00000327116 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia | EH-domain containing 3; Plays a role in endocytic transport | 0.739 |
| PLEKHH2 | FAM65A | ENSP00000282406 | ENSP00000400099 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia | family with sequence similarity 65, member A; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...] | 0.597 |
| PLEKHH2 | SH2D4A | ENSP00000282406 | ENSP00000265807 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia | SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function | 0.874 |
| SH2D4A | ABP1 | ENSP00000265807 | ENSP00000354193 | SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function | amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function | 0.687 |
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