node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAA2 | ACACA | ENSP00000285093 | ENSP00000344789 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | acetyl-CoA carboxylase alpha | 0.809 |
ACAA2 | ACACB | ENSP00000285093 | ENSP00000341044 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.820 |
ACAA2 | ACAT1 | ENSP00000285093 | ENSP00000265838 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.972 |
ACAA2 | EHHADH | ENSP00000285093 | ENSP00000231887 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.998 |
ACAA2 | HADH | ENSP00000285093 | ENSP00000385638 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA | 0.987 |
ACAA2 | HADHA | ENSP00000285093 | ENSP00000370023 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.999 |
ACAA2 | HMGCS1 | ENSP00000285093 | ENSP00000322706 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.983 |
ACAA2 | HMGCS2 | ENSP00000285093 | ENSP00000358414 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.984 |
ACAA2 | OXCT1 | ENSP00000285093 | ENSP00000196371 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.859 |
ACAA2 | OXCT2 | ENSP00000285093 | ENSP00000361914 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 3-oxoacid CoA transferase 2; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.834 |
ACACA | ACAA2 | ENSP00000344789 | ENSP00000285093 | acetyl-CoA carboxylase alpha | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 0.809 |
ACACA | ACACB | ENSP00000344789 | ENSP00000341044 | acetyl-CoA carboxylase alpha | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.999 |
ACACA | ACAT1 | ENSP00000344789 | ENSP00000265838 | acetyl-CoA carboxylase alpha | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.980 |
ACACA | EHHADH | ENSP00000344789 | ENSP00000231887 | acetyl-CoA carboxylase alpha | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.775 |
ACACA | HADH | ENSP00000344789 | ENSP00000385638 | acetyl-CoA carboxylase alpha | hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA | 0.655 |
ACACA | HADHA | ENSP00000344789 | ENSP00000370023 | acetyl-CoA carboxylase alpha | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.745 |
ACACA | HMGCS1 | ENSP00000344789 | ENSP00000322706 | acetyl-CoA carboxylase alpha | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.658 |
ACACA | HMGCS2 | ENSP00000344789 | ENSP00000358414 | acetyl-CoA carboxylase alpha | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.632 |
ACACA | OXCT1 | ENSP00000344789 | ENSP00000196371 | acetyl-CoA carboxylase alpha | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.880 |
ACACA | OXCT2 | ENSP00000344789 | ENSP00000361914 | acetyl-CoA carboxylase alpha | 3-oxoacid CoA transferase 2; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.840 |