| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C11orf65 | EXPH5 | ENSP00000376799 | ENSP00000265843 | chromosome 11 open reading frame 65 | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | 0.581 |
| CHML | EXPH5 | ENSP00000355511 | ENSP00000265843 | choroideremia-like (Rab escort protein 2); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | 0.680 |
| CHML | RAB27A | ENSP00000355511 | ENSP00000337761 | choroideremia-like (Rab escort protein 2); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family | RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse | 0.726 |
| CHML | SYT1 | ENSP00000355511 | ENSP00000261205 | choroideremia-like (Rab escort protein 2); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.440 |
| CHML | SYTL2 | ENSP00000355511 | ENSP00000346576 | choroideremia-like (Rab escort protein 2); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family | synaptotagmin-like 2 | 0.664 |
| COX5A | EXPH5 | ENSP00000317780 | ENSP00000265843 | cytochrome c oxidase subunit Va; This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | 0.589 |
| COX5A | MLPH | ENSP00000317780 | ENSP00000264605 | cytochrome c oxidase subunit Va; This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | melanophilin; Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A | 0.610 |
| COX5A | MYO5A | ENSP00000317780 | ENSP00000382177 | cytochrome c oxidase subunit Va; This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | 0.564 |
| COX5A | RAB27A | ENSP00000317780 | ENSP00000337761 | cytochrome c oxidase subunit Va; This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse | 0.689 |
| COX5A | SYTL2 | ENSP00000317780 | ENSP00000346576 | cytochrome c oxidase subunit Va; This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | synaptotagmin-like 2 | 0.563 |
| EXPH5 | C11orf65 | ENSP00000265843 | ENSP00000376799 | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | chromosome 11 open reading frame 65 | 0.581 |
| EXPH5 | CHML | ENSP00000265843 | ENSP00000355511 | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | choroideremia-like (Rab escort protein 2); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family | 0.680 |
| EXPH5 | COX5A | ENSP00000265843 | ENSP00000317780 | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | cytochrome c oxidase subunit Va; This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | 0.589 |
| EXPH5 | FAM102B | ENSP00000265843 | ENSP00000359052 | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | family with sequence similarity 102, member B | 0.566 |
| EXPH5 | MLPH | ENSP00000265843 | ENSP00000264605 | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | melanophilin; Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A | 0.750 |
| EXPH5 | MYO5A | ENSP00000265843 | ENSP00000382177 | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | 0.655 |
| EXPH5 | OR6C76 | ENSP00000265843 | ENSP00000328402 | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | olfactory receptor, family 6, subfamily C, member 76; Odorant receptor (Potential) | 0.568 |
| EXPH5 | RAB27A | ENSP00000265843 | ENSP00000337761 | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse | 0.951 |
| EXPH5 | SYT1 | ENSP00000265843 | ENSP00000261205 | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.687 |
| EXPH5 | SYTL2 | ENSP00000265843 | ENSP00000346576 | exophilin 5; May act as Rab effector protein and play a role in vesicle trafficking | synaptotagmin-like 2 | 0.860 |
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