node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP51A1 | FDFT1 | ENSP00000003100 | ENSP00000220584 | cytochrome P450, family 51, subfamily A, polypeptide 1 | farnesyl-diphosphate farnesyltransferase 1 | 0.993 |
CYP51A1 | LSS | ENSP00000003100 | ENSP00000348762 | cytochrome P450, family 51, subfamily A, polypeptide 1 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.999 |
CYP51A1 | MSMO1 | ENSP00000003100 | ENSP00000261507 | cytochrome P450, family 51, subfamily A, polypeptide 1 | methylsterol monooxygenase 1 | 0.997 |
CYP51A1 | NSDHL | ENSP00000003100 | ENSP00000359297 | cytochrome P450, family 51, subfamily A, polypeptide 1 | NAD(P) dependent steroid dehydrogenase-like | 0.941 |
CYP51A1 | SDR42E1 | ENSP00000003100 | ENSP00000332407 | cytochrome P450, family 51, subfamily A, polypeptide 1 | short chain dehydrogenase/reductase family 42E, member 1 | 0.884 |
CYP51A1 | SIGMAR1 | ENSP00000003100 | ENSP00000277010 | cytochrome P450, family 51, subfamily A, polypeptide 1 | sigma non-opioid intracellular receptor 1 | 0.957 |
CYP51A1 | SQLE | ENSP00000003100 | ENSP00000265896 | cytochrome P450, family 51, subfamily A, polypeptide 1 | squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway | 0.978 |
CYP51A1 | SREBF2 | ENSP00000003100 | ENSP00000354476 | cytochrome P450, family 51, subfamily A, polypeptide 1 | sterol regulatory element binding transcription factor 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes | 0.948 |
CYP51A1 | TM7SF2 | ENSP00000003100 | ENSP00000279263 | cytochrome P450, family 51, subfamily A, polypeptide 1 | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | 0.994 |
CYP51A1 | UBC | ENSP00000003100 | ENSP00000344818 | cytochrome P450, family 51, subfamily A, polypeptide 1 | ubiquitin C | 0.986 |
FDFT1 | CYP51A1 | ENSP00000220584 | ENSP00000003100 | farnesyl-diphosphate farnesyltransferase 1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.993 |
FDFT1 | LSS | ENSP00000220584 | ENSP00000348762 | farnesyl-diphosphate farnesyltransferase 1 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.977 |
FDFT1 | MSMO1 | ENSP00000220584 | ENSP00000261507 | farnesyl-diphosphate farnesyltransferase 1 | methylsterol monooxygenase 1 | 0.993 |
FDFT1 | NSDHL | ENSP00000220584 | ENSP00000359297 | farnesyl-diphosphate farnesyltransferase 1 | NAD(P) dependent steroid dehydrogenase-like | 0.929 |
FDFT1 | SDR42E1 | ENSP00000220584 | ENSP00000332407 | farnesyl-diphosphate farnesyltransferase 1 | short chain dehydrogenase/reductase family 42E, member 1 | 0.871 |
FDFT1 | SQLE | ENSP00000220584 | ENSP00000265896 | farnesyl-diphosphate farnesyltransferase 1 | squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway | 0.980 |
FDFT1 | SREBF2 | ENSP00000220584 | ENSP00000354476 | farnesyl-diphosphate farnesyltransferase 1 | sterol regulatory element binding transcription factor 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes | 0.973 |
FDFT1 | TM7SF2 | ENSP00000220584 | ENSP00000279263 | farnesyl-diphosphate farnesyltransferase 1 | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | 0.800 |
FDFT1 | UBC | ENSP00000220584 | ENSP00000344818 | farnesyl-diphosphate farnesyltransferase 1 | ubiquitin C | 0.988 |
LSS | CYP51A1 | ENSP00000348762 | ENSP00000003100 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.999 |