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GID4 GID4 WDR26 WDR26 RANBP9 RANBP9 ARMC8 ARMC8 MPHOSPH8 MPHOSPH8 GID8 GID8 MAEA MAEA RMND5B RMND5B MKLN1 MKLN1 RANBP10 RANBP10 RMND5A RMND5A
"GID8" - GID complex subunit 8 homolog (S. cerevisiae) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
GID8GID complex subunit 8 homolog (S. cerevisiae) (228 aa)    
Predicted Functional Partners:
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae) (391 aa)
        score_image   score_image   0.992
ARMC8
armadillo repeat containing 8 (659 aa)
        score_image   score_image   0.980
WDR26
WD repeat domain 26; May be involved in MAPK pathways (661 aa)
        score_image   score_image   0.980
MAEA
macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events (396 aa)
      score_image score_image   score_image score_image 0.978
RANBP9
RAN binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] (729 aa)
        score_image   score_image score_image 0.976
MKLN1
muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) (735 aa)
        score_image   score_image   0.941
RMND5B
required for meiotic nuclear division 5 homolog B (S. cerevisiae) (393 aa)
        score_image   score_image   0.927
GID4
GID complex subunit 4, VID24 homolog (S. cerevisiae) (300 aa)
        score_image   score_image   0.912
MPHOSPH8
M-phase phosphoprotein 8; Involved in transcriptional regulation. Specifically recognizes and binds methylated ’Lys-9’ of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression (860 aa)
        score_image   score_image   0.868
RANBP10
RAN binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] (620 aa)
        score_image   score_image   0.772
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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