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SLC15A1 SLC15A1 TAS1R3 TAS1R3 SLC2A2 SLC2A2 SLC2A5 SLC2A5 TAS1R2 TAS1R2 GNAT3 GNAT3 IGF1R IGF1R SLC5A1 SLC5A1 EGFR EGFR HSPA4 HSPA4 FOXL1 FOXL1
"SLC5A1" - solute carrier family 5 (sodium/glucose cotransporter), member 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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protein homology
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SLC5A1solute carrier family 5 (sodium/glucose cotransporter), member 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2-1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules (664 aa)    
Predicted Functional Partners:
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2; Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (524 aa)
          score_image score_image   0.988
EGFR
epidermal growth factor receptor (1210 aa)
        score_image   score_image   0.932
FOXL1
forkhead box L1; Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity) (345 aa)
            score_image   0.908
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5; Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter (501 aa)
            score_image   0.858
TAS1R3
taste receptor, type 1, member 3; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (852 aa)
            score_image   0.821
TAS1R2
taste receptor, type 1, member 2; Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (839 aa)
            score_image   0.816
IGF1R
insulin-like growth factor 1 receptor; Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc [...] (1367 aa)
            score_image   0.816
HSPA4
heat shock 70kDa protein 4 (840 aa)
            score_image   0.800
SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products (708 aa)
            score_image   0.775
GNAT3
guanine nucleotide binding protein, alpha transducing 3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultima [...] (354 aa)
            score_image   0.755
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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