node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CABP1 | CACNA1C | ENSP00000317310 | ENSP00000266376 | calcium binding protein 1; Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similari [...] | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.985 |
CACNA1C | CABP1 | ENSP00000266376 | ENSP00000317310 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calcium binding protein 1; Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similari [...] | 0.985 |
CACNA1C | CACNA2D1 | ENSP00000266376 | ENSP00000349320 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calcium channel, voltage-dependent, alpha 2/delta subunit 1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity) | 0.957 |
CACNA1C | CACNB1 | ENSP00000266376 | ENSP00000377840 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calcium channel, voltage-dependent, beta 1 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | 0.971 |
CACNA1C | CACNB2 | ENSP00000266376 | ENSP00000320025 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calcium channel, voltage-dependent, beta 2 subunit | 0.987 |
CACNA1C | CACNB3 | ENSP00000266376 | ENSP00000301050 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calcium channel, voltage-dependent, beta 3 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | 0.995 |
CACNA1C | CACNB4 | ENSP00000266376 | ENSP00000438949 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calcium channel, voltage-dependent, beta 4 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | 0.956 |
CACNA1C | CALM1 | ENSP00000266376 | ENSP00000349467 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calmodulin 1 (phosphorylase kinase, delta) | 0.972 |
CACNA1C | CALM2 | ENSP00000266376 | ENSP00000272298 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calmodulin 2 (phosphorylase kinase, delta) | 0.988 |
CACNA1C | RYR1 | ENSP00000266376 | ENSP00000352608 | calcium channel, voltage-dependent, L type, alpha 1C subunit | ryanodine receptor 1 (skeletal); Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Requi [...] | 0.967 |
CACNA1C | RYR2 | ENSP00000266376 | ENSP00000355533 | calcium channel, voltage-dependent, L type, alpha 1C subunit | ryanodine receptor 2 (cardiac); Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development | 0.990 |
CACNA2D1 | CACNA1C | ENSP00000349320 | ENSP00000266376 | calcium channel, voltage-dependent, alpha 2/delta subunit 1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity) | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.957 |
CACNA2D1 | CACNB1 | ENSP00000349320 | ENSP00000377840 | calcium channel, voltage-dependent, alpha 2/delta subunit 1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity) | calcium channel, voltage-dependent, beta 1 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | 0.972 |
CACNA2D1 | CACNB2 | ENSP00000349320 | ENSP00000320025 | calcium channel, voltage-dependent, alpha 2/delta subunit 1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity) | calcium channel, voltage-dependent, beta 2 subunit | 0.967 |
CACNA2D1 | CACNB3 | ENSP00000349320 | ENSP00000301050 | calcium channel, voltage-dependent, alpha 2/delta subunit 1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity) | calcium channel, voltage-dependent, beta 3 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | 0.972 |
CACNA2D1 | CACNB4 | ENSP00000349320 | ENSP00000438949 | calcium channel, voltage-dependent, alpha 2/delta subunit 1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity) | calcium channel, voltage-dependent, beta 4 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | 0.963 |
CACNA2D1 | RYR1 | ENSP00000349320 | ENSP00000352608 | calcium channel, voltage-dependent, alpha 2/delta subunit 1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity) | ryanodine receptor 1 (skeletal); Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Requi [...] | 0.606 |
CACNB1 | CACNA1C | ENSP00000377840 | ENSP00000266376 | calcium channel, voltage-dependent, beta 1 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.971 |
CACNB1 | CACNA2D1 | ENSP00000377840 | ENSP00000349320 | calcium channel, voltage-dependent, beta 1 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | calcium channel, voltage-dependent, alpha 2/delta subunit 1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity) | 0.972 |
CACNB1 | CACNB2 | ENSP00000377840 | ENSP00000320025 | calcium channel, voltage-dependent, beta 1 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | calcium channel, voltage-dependent, beta 2 subunit | 0.902 |