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FKBP7 FKBP7 TMX2 TMX2 ERO1LB ERO1LB TXNDC11 TXNDC11 ERP27 ERP27 ERO1L ERO1L PDIA3 PDIA3 CALR CALR PDIA4 PDIA4 FKBP2 FKBP2 FKBP14 FKBP14
"ERP27" - endoplasmic reticulum protein 27 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
ERP27endoplasmic reticulum protein 27 (273 aa)    
Predicted Functional Partners:
PDIA3
protein disulfide isomerase family A, member 3 (505 aa)
      score_image score_image   score_image   0.994
PDIA4
protein disulfide isomerase family A, member 4 (645 aa)
      score_image score_image   score_image   0.831
CALR
calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity) (417 aa)
      score_image score_image   score_image   0.779
ERO1LB
ERO1-like beta (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently [...] (467 aa)
        score_image   score_image   0.732
FKBP7
FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis (222 aa)
        score_image   score_image   0.703
FKBP14
FK506 binding protein 14, 22 kDa; PPIases accelerate the folding of proteins during protein synthesis (211 aa)
        score_image   score_image   0.698
TMX2
thioredoxin-related transmembrane protein 2 (296 aa)
            score_image   0.697
TXNDC11
thioredoxin domain containing 11; May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation (958 aa)
      score_image score_image   score_image   0.694
ERO1L
ERO1-like (S. cerevisiae); Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of g [...] (468 aa)
        score_image   score_image   0.676
FKBP2
FK506 binding protein 2, 13kDa; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (142 aa)
        score_image   score_image   0.674
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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