node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGXT2L1 | ETNK1 | ENSP00000296486 | ENSP00000266517 | alanine-glyoxylate aminotransferase 2-like 1; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | 0.900 |
AGXT2L1 | PCYT2 | ENSP00000296486 | ENSP00000442050 | alanine-glyoxylate aminotransferase 2-like 1; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | phosphate cytidylyltransferase 2, ethanolamine; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine | 0.900 |
AGXT2L1 | PHOSPHO1 | ENSP00000296486 | ENSP00000406909 | alanine-glyoxylate aminotransferase 2-like 1; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | phosphatase, orphan 1; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization | 0.900 |
DRD1 | ETNK1 | ENSP00000327652 | ENSP00000266517 | dopamine receptor D1; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | 0.742 |
DRD1 | SOX5 | ENSP00000327652 | ENSP00000398273 | dopamine receptor D1; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase | SRY (sex determining region Y)-box 5 | 0.685 |
EPT1 | ETNK1 | ENSP00000260585 | ENSP00000266517 | ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | 0.680 |
EPT1 | PCYT2 | ENSP00000260585 | ENSP00000442050 | ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway | phosphate cytidylyltransferase 2, ethanolamine; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine | 0.952 |
EPT1 | UBC | ENSP00000260585 | ENSP00000344818 | ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway | ubiquitin C | 0.516 |
ETNK1 | AGXT2L1 | ENSP00000266517 | ENSP00000296486 | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | alanine-glyoxylate aminotransferase 2-like 1; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | 0.900 |
ETNK1 | DRD1 | ENSP00000266517 | ENSP00000327652 | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | dopamine receptor D1; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase | 0.742 |
ETNK1 | EPT1 | ENSP00000266517 | ENSP00000260585 | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway | 0.680 |
ETNK1 | ORC4 | ENSP00000266517 | ENSP00000264169 | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | origin recognition complex, subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication | 0.748 |
ETNK1 | PCYT2 | ENSP00000266517 | ENSP00000442050 | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | phosphate cytidylyltransferase 2, ethanolamine; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine | 0.954 |
ETNK1 | PHOSPHO1 | ENSP00000266517 | ENSP00000406909 | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | phosphatase, orphan 1; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization | 0.900 |
ETNK1 | SOX5 | ENSP00000266517 | ENSP00000398273 | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | SRY (sex determining region Y)-box 5 | 0.811 |
ETNK1 | TCF3 | ENSP00000266517 | ENSP00000262965 | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region | 0.800 |
ETNK1 | TTC3 | ENSP00000266517 | ENSP00000346791 | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | tetratricopeptide repeat domain 3 | 0.748 |
ETNK1 | UBC | ENSP00000266517 | ENSP00000344818 | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | ubiquitin C | 0.906 |
ORC4 | ETNK1 | ENSP00000264169 | ENSP00000266517 | origin recognition complex, subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication | ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | 0.748 |
ORC4 | UBC | ENSP00000264169 | ENSP00000344818 | origin recognition complex, subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication | ubiquitin C | 0.980 |