SLC15A4 protein (Homo sapiens) - STRING network view

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SLC15A4

solute carrier family 15, member 4; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (577 aa)

Predicted Functional Partners:

UBC

0.890

PPIL4

0.716

NOD2

0.648

SF3A1

0.620

SLC15A3

0.599

PQBP1

0.553

SLC37A2

0.550

RASGRP3

0.507

C7orf72

0.503

IER3

0.495

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C7orf72	RASGRP3	ENSP00000297001	ENSP00000384192	chromosome 7 open reading frame 72	RAS guanyl releasing protein 3 (calcium and DAG-regulated); Guanine nucleotide exchange factor (GEF) for Ras and Rap1	0.418
C7orf72	SLC15A4	ENSP00000297001	ENSP00000266771	chromosome 7 open reading frame 72	solute carrier family 15, member 4; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides	0.503
IER3	SLC15A3	ENSP00000259874	ENSP00000227880	immediate early response 3; May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment	solute carrier family 15, member 3; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity)	0.593
IER3	SLC15A4	ENSP00000259874	ENSP00000266771	immediate early response 3; May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment	solute carrier family 15, member 4; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides	0.495
IER3	SLC37A2	ENSP00000259874	ENSP00000311833	immediate early response 3; May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment	solute carrier family 37 (glycerol-3-phosphate transporter), member 2	0.593
NOD2	SLC15A3	ENSP00000300589	ENSP00000227880	nucleotide-binding oligomerization domain containing 2; Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK- gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS)	solute carrier family 15, member 3; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity)	0.602
NOD2	SLC15A4	ENSP00000300589	ENSP00000266771	nucleotide-binding oligomerization domain containing 2; Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK- gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS)	solute carrier family 15, member 4; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides	0.648
NOD2	UBC	ENSP00000300589	ENSP00000344818	nucleotide-binding oligomerization domain containing 2; Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK- gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS)	ubiquitin C	0.692
PPIL4	PQBP1	ENSP00000253329	ENSP00000218224	peptidylprolyl isomerase (cyclophilin)-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)	polyglutamine binding protein 1	0.590
PPIL4	SF3A1	ENSP00000253329	ENSP00000215793	peptidylprolyl isomerase (cyclophilin)-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)	splicing factor 3a, subunit 1, 120kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex	0.686
PPIL4	SLC15A3	ENSP00000253329	ENSP00000227880	peptidylprolyl isomerase (cyclophilin)-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)	solute carrier family 15, member 3; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity)	0.598
PPIL4	SLC15A4	ENSP00000253329	ENSP00000266771	peptidylprolyl isomerase (cyclophilin)-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)	solute carrier family 15, member 4; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides	0.716
PPIL4	UBC	ENSP00000253329	ENSP00000344818	peptidylprolyl isomerase (cyclophilin)-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)	ubiquitin C	0.817
PQBP1	PPIL4	ENSP00000218224	ENSP00000253329	polyglutamine binding protein 1	peptidylprolyl isomerase (cyclophilin)-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)	0.590
PQBP1	SF3A1	ENSP00000218224	ENSP00000215793	polyglutamine binding protein 1	splicing factor 3a, subunit 1, 120kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex	0.498
PQBP1	SLC15A3	ENSP00000218224	ENSP00000227880	polyglutamine binding protein 1	solute carrier family 15, member 3; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity)	0.553
PQBP1	SLC15A4	ENSP00000218224	ENSP00000266771	polyglutamine binding protein 1	solute carrier family 15, member 4; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides	0.553
RASGRP3	C7orf72	ENSP00000384192	ENSP00000297001	RAS guanyl releasing protein 3 (calcium and DAG-regulated); Guanine nucleotide exchange factor (GEF) for Ras and Rap1	chromosome 7 open reading frame 72	0.418
RASGRP3	SLC15A4	ENSP00000384192	ENSP00000266771	RAS guanyl releasing protein 3 (calcium and DAG-regulated); Guanine nucleotide exchange factor (GEF) for Ras and Rap1	solute carrier family 15, member 4; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides	0.507
SF3A1	PPIL4	ENSP00000215793	ENSP00000253329	splicing factor 3a, subunit 1, 120kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex	peptidylprolyl isomerase (cyclophilin)-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)	0.686

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