node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA1 | CCNB1 | ENSP00000255465 | ENSP00000256442 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.997 |
CCNA1 | CCNE1 | ENSP00000255465 | ENSP00000262643 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | 0.959 |
CCNA1 | CCNE2 | ENSP00000255465 | ENSP00000309181 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | 0.600 |
CCNA1 | CDC25A | ENSP00000255465 | ENSP00000303706 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cell division cycle 25 homolog A (S. pombe); Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro | 0.997 |
CCNA1 | CDK2 | ENSP00000255465 | ENSP00000266970 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...] | 0.999 |
CCNA1 | CDKN1A | ENSP00000255465 | ENSP00000244741 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex | 0.999 |
CCNA1 | CDKN1B | ENSP00000255465 | ENSP00000228872 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry | 0.997 |
CCNA1 | RB1 | ENSP00000255465 | ENSP00000267163 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.992 |
CCNA1 | RBL1 | ENSP00000255465 | ENSP00000362768 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | retinoblastoma-like 1 (p107); Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 ’Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with [...] | 0.970 |
CCNA2 | CCNB1 | ENSP00000274026 | ENSP00000256442 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.993 |
CCNA2 | CCNE1 | ENSP00000274026 | ENSP00000262643 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | 0.960 |
CCNA2 | CCNE2 | ENSP00000274026 | ENSP00000309181 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | 0.618 |
CCNA2 | CDC25A | ENSP00000274026 | ENSP00000303706 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cell division cycle 25 homolog A (S. pombe); Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro | 0.787 |
CCNA2 | CDK2 | ENSP00000274026 | ENSP00000266970 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...] | 0.999 |
CCNA2 | CDKN1A | ENSP00000274026 | ENSP00000244741 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex | 0.999 |
CCNA2 | CDKN1B | ENSP00000274026 | ENSP00000228872 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry | 0.999 |
CCNA2 | RB1 | ENSP00000274026 | ENSP00000267163 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.999 |
CCNA2 | RBL1 | ENSP00000274026 | ENSP00000362768 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | retinoblastoma-like 1 (p107); Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 ’Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with [...] | 0.995 |
CCNB1 | CCNA1 | ENSP00000256442 | ENSP00000255465 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | 0.997 |
CCNB1 | CCNA2 | ENSP00000256442 | ENSP00000274026 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | 0.993 |