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BUD13 BUD13 PRPF19 PRPF19 CDC40 CDC40 CDC5L CDC5L BUD31 BUD31 DCAF12L2 DCAF12L2 RNF113B RNF113B UBE2U UBE2U DNAAF2 DNAAF2 PIH1D1 PIH1D1 PIH1D2 PIH1D2
"RNF113B" - ring finger protein 113B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Experiments
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[Homology]
Score
RNF113Bring finger protein 113B (322 aa)    
Predicted Functional Partners:
CDC5L
CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (802 aa)
       score_image score_image   score_image   0.892
PRPF19
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] (504 aa)
       score_image score_image   score_image   0.860
DNAAF2
dynein, axonemal, assembly factor 2; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment (837 aa)
         score_image   score_image   0.763
PIH1D2
PIH1 domain containing 2 (315 aa)
         score_image   score_image   0.763
PIH1D1
PIH1 domain containing 1 (290 aa)
         score_image   score_image   0.763
BUD31
BUD31 homolog (S. cerevisiae) (144 aa)
         score_image       0.722
BUD13
BUD13 homolog (S. cerevisiae) (619 aa)
       score_image     score_image   0.705
CDC40
cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing (579 aa)
         score_image   score_image   0.654
DCAF12L2
DDB1 and CUL4 associated factor 12-like 2 (463 aa)
             score_image   0.636
UBE2U
ubiquitin-conjugating enzyme E2U (putative); Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity) (226 aa)
         score_image   score_image   0.597
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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