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STRINGSTRING
NOL10 NOL10 NOP9 NOP9 TBL3 TBL3 NOP56 NOP56 PDCD11 PDCD11 CIRH1A CIRH1A NOP58 NOP58 RBM19 RBM19 MKI67IP MKI67IP RRP12 RRP12 HEATR1 HEATR1
NOP9 nucleolar protein homolog in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOP9NOP9 nucleolar protein homolog (yeast) (636 aa)    
Predicted Functional Partners:
CIRH1A
cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (686 aa)
      score_image score_image   score_image   0.960
RBM19
RNA binding motif protein 19; Plays a role in embryo pre-implantation development (By similarity) (960 aa)
      score_image score_image   score_image   0.950
MKI67IP
MKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa)
      score_image score_image       0.924
TBL3
transducin (beta)-like 3 (808 aa)
      score_image score_image   score_image   0.922
RRP12
ribosomal RNA processing 12 homolog (S. cerevisiae) (1297 aa)
      score_image score_image   score_image   0.916
NOL10
nucleolar protein 10 (688 aa)
      score_image score_image   score_image   0.901
NOP56
NOP56 ribonucleoprotein homolog (yeast); Involved in the early to middle stages of 60S ribosomal subunit biogenesis (594 aa)
      score_image score_image   score_image   0.898
NOP58
NOP58 ribonucleoprotein homolog (yeast); Required for 60S ribosomal subunit biogenesis (By similarity) (529 aa)
      score_image score_image   score_image   0.898
PDCD11
programmed cell death 11; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (1871 aa)
      score_image score_image   score_image   0.897
HEATR1
HEAT repeat containing 1; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity) (2144 aa)
      score_image score_image   score_image   0.895
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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