| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACLY | AIFM3 | ENSP00000253792 | ENSP00000382120 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.608 |
| ACLY | ALDH4A1 | ENSP00000253792 | ENSP00000290597 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | aldehyde dehydrogenase 4 family, member A1 | 0.702 |
| ACLY | D2HGDH | ENSP00000253792 | ENSP00000315351 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | D-2-hydroxyglutarate dehydrogenase; Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate | 0.507 |
| ACLY | GLS | ENSP00000253792 | ENSP00000317379 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity | 0.435 |
| ACLY | GLUD1 | ENSP00000253792 | ENSP00000277865 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | glutamate dehydrogenase 1; May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity) | 0.844 |
| ACLY | GLUD2 | ENSP00000253792 | ENSP00000327589 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission | 0.815 |
| ACLY | GLUL | ENSP00000253792 | ENSP00000307900 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts | 0.686 |
| ACLY | L2HGDH | ENSP00000253792 | ENSP00000267436 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | L-2-hydroxyglutarate dehydrogenase | 0.703 |
| AIFM3 | ACLY | ENSP00000382120 | ENSP00000253792 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.608 |
| AIFM3 | ALDH4A1 | ENSP00000382120 | ENSP00000290597 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | aldehyde dehydrogenase 4 family, member A1 | 0.459 |
| AIFM3 | GLUD1 | ENSP00000382120 | ENSP00000277865 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | glutamate dehydrogenase 1; May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity) | 0.422 |
| AIFM3 | GLUD2 | ENSP00000382120 | ENSP00000327589 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission | 0.422 |
| AIFM3 | GLUL | ENSP00000382120 | ENSP00000307900 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts | 0.458 |
| AIFM3 | L2HGDH | ENSP00000382120 | ENSP00000267436 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | L-2-hydroxyglutarate dehydrogenase | 0.676 |
| ALDH4A1 | ACLY | ENSP00000290597 | ENSP00000253792 | aldehyde dehydrogenase 4 family, member A1 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.702 |
| ALDH4A1 | AIFM3 | ENSP00000290597 | ENSP00000382120 | aldehyde dehydrogenase 4 family, member A1 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.459 |
| ALDH4A1 | GAD1 | ENSP00000290597 | ENSP00000350928 | aldehyde dehydrogenase 4 family, member A1 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | 0.927 |
| ALDH4A1 | GAD2 | ENSP00000290597 | ENSP00000259271 | aldehyde dehydrogenase 4 family, member A1 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | 0.928 |
| ALDH4A1 | GLS | ENSP00000290597 | ENSP00000317379 | aldehyde dehydrogenase 4 family, member A1 | glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity | 0.914 |
| ALDH4A1 | GLUD1 | ENSP00000290597 | ENSP00000277865 | aldehyde dehydrogenase 4 family, member A1 | glutamate dehydrogenase 1; May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity) | 0.929 |
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