node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSL3 | RTN1 | ENSP00000350012 | ENSP00000267484 | acyl-CoA synthetase long-chain family member 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | 0.712 |
AGL | RTN1 | ENSP00000294724 | ENSP00000267484 | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | 0.733 |
AGL | RTN3 | ENSP00000294724 | ENSP00000344106 | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | reticulon 3 | 0.733 |
EXOC3 | RTN1 | ENSP00000323377 | ENSP00000267484 | exocyst complex component 3; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | 0.824 |
REEP5 | RTN1 | ENSP00000368959 | ENSP00000267484 | receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | 0.754 |
REEP5 | RTN3 | ENSP00000368959 | ENSP00000344106 | receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors | reticulon 3 | 0.754 |
RTN1 | ACSL3 | ENSP00000267484 | ENSP00000350012 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | acyl-CoA synthetase long-chain family member 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) | 0.712 |
RTN1 | AGL | ENSP00000267484 | ENSP00000294724 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 0.733 |
RTN1 | EXOC3 | ENSP00000267484 | ENSP00000323377 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | exocyst complex component 3; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | 0.824 |
RTN1 | REEP5 | ENSP00000267484 | ENSP00000368959 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors | 0.754 |
RTN1 | RTN3 | ENSP00000267484 | ENSP00000344106 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | reticulon 3 | 0.762 |
RTN1 | SNX1 | ENSP00000267484 | ENSP00000453785 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | sorting nexin 1; May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | 0.726 |
RTN1 | SNX2 | ENSP00000267484 | ENSP00000368831 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | sorting nexin 2; May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | 0.733 |
RTN1 | SPAST | ENSP00000267484 | ENSP00000320885 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches (By similarity) | 0.976 |
RTN1 | WDFY1 | ENSP00000267484 | ENSP00000233055 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | WD repeat and FYVE domain containing 1 | 0.726 |
RTN1 | WDFY2 | ENSP00000267484 | ENSP00000298125 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | WD repeat and FYVE domain containing 2 | 0.726 |
RTN3 | AGL | ENSP00000344106 | ENSP00000294724 | reticulon 3 | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 0.733 |
RTN3 | REEP5 | ENSP00000344106 | ENSP00000368959 | reticulon 3 | receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors | 0.754 |
RTN3 | RTN1 | ENSP00000344106 | ENSP00000267484 | reticulon 3 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells | 0.762 |
RTN3 | SNX1 | ENSP00000344106 | ENSP00000453785 | reticulon 3 | sorting nexin 1; May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | 0.654 |