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CCDC58 CCDC58 CRYZL1 CRYZL1 VAT1 VAT1 RTN4IP1 RTN4IP1 PTGR2 PTGR2 VAT1L VAT1L TP53I3 TP53I3 PRDX6 PRDX6
"PTGR2" - prostaglandin reductase 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
coexpression edge
co-expression
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protein homology
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PTGR2prostaglandin reductase 2; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity) (351 aa)    
Predicted Functional Partners:
PRDX6
peroxiredoxin 6; Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury (224 aa)
       score_image     score_image   0.488
CCDC58
coiled-coil domain containing 58 (144 aa)
             score_image   0.443
CRYZL1
crystallin, zeta (quinone reductase)-like 1 (349 aa)
       score_image     score_image   0.434
RTN4IP1
reticulon 4 interacting protein 1; Appears to be a potent inhibitor of regeneration following spinal cord injury (396 aa)
       score_image     score_image   0.424
VAT1
vesicle amine transport protein 1 homolog (T. californica); Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (393 aa)
       score_image     score_image   0.424
VAT1L
vesicle amine transport protein 1 homolog (T. californica)-like (419 aa)
       score_image     score_image   0.424
TP53I3
tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) (332 aa)
       score_image     score_image   0.424
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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