| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASAH2 | GMPR | ENSP00000378897 | ENSP00000259727 | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabo [...] | guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides | 0.497 |
| ASAH2 | ZNF280D | ENSP00000378897 | ENSP00000267807 | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabo [...] | zinc finger protein 280D; May function as a transcription factor | 0.521 |
| GMPR | ASAH2 | ENSP00000259727 | ENSP00000378897 | guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabo [...] | 0.497 |
| GMPR | ZNF280D | ENSP00000259727 | ENSP00000267807 | guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides | zinc finger protein 280D; May function as a transcription factor | 0.507 |
| KDM2A | ZNF280D | ENSP00000432786 | ENSP00000267807 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 280D; May function as a transcription factor | 0.526 |
| KDM2B | ZNF280D | ENSP00000366271 | ENSP00000267807 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 280D; May function as a transcription factor | 0.526 |
| QRICH1 | ZNF280D | ENSP00000350094 | ENSP00000267807 | glutamine-rich 1 | zinc finger protein 280D; May function as a transcription factor | 0.760 |
| XRN1 | ZNF280D | ENSP00000264951 | ENSP00000267807 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 280D; May function as a transcription factor | 0.543 |
| ZMYM2 | ZMYM4 | ENSP00000372322 | ENSP00000322915 | zinc finger, MYM-type 2 | zinc finger, MYM-type 4; Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.601 |
| ZMYM2 | ZNF280D | ENSP00000372322 | ENSP00000267807 | zinc finger, MYM-type 2 | zinc finger protein 280D; May function as a transcription factor | 0.805 |
| ZMYM3 | ZNF280D | ENSP00000322845 | ENSP00000267807 | zinc finger, MYM-type 3; Plays a role in the regulation of cell morphology and cytoskeletal organization | zinc finger protein 280D; May function as a transcription factor | 0.809 |
| ZMYM4 | ZMYM2 | ENSP00000322915 | ENSP00000372322 | zinc finger, MYM-type 4; Plays a role in the regulation of cell morphology and cytoskeletal organization | zinc finger, MYM-type 2 | 0.601 |
| ZMYM4 | ZNF280D | ENSP00000322915 | ENSP00000267807 | zinc finger, MYM-type 4; Plays a role in the regulation of cell morphology and cytoskeletal organization | zinc finger protein 280D; May function as a transcription factor | 0.805 |
| ZMYM6 | ZNF280D | ENSP00000349708 | ENSP00000267807 | zinc finger, MYM-type 6 | zinc finger protein 280D; May function as a transcription factor | 0.805 |
| ZNF280D | ASAH2 | ENSP00000267807 | ENSP00000378897 | zinc finger protein 280D; May function as a transcription factor | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabo [...] | 0.521 |
| ZNF280D | GMPR | ENSP00000267807 | ENSP00000259727 | zinc finger protein 280D; May function as a transcription factor | guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides | 0.507 |
| ZNF280D | KDM2A | ENSP00000267807 | ENSP00000432786 | zinc finger protein 280D; May function as a transcription factor | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.526 |
| ZNF280D | KDM2B | ENSP00000267807 | ENSP00000366271 | zinc finger protein 280D; May function as a transcription factor | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | 0.526 |
| ZNF280D | QRICH1 | ENSP00000267807 | ENSP00000350094 | zinc finger protein 280D; May function as a transcription factor | glutamine-rich 1 | 0.760 |
| ZNF280D | XRN1 | ENSP00000267807 | ENSP00000264951 | zinc finger protein 280D; May function as a transcription factor | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | 0.543 |
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