MFAP1 protein (Homo sapiens) - STRING network view

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MFAP1

microfibrillar-associated protein 1; Component of the elastin-associated microfibrils (439 aa)

Predicted Functional Partners:

PRPF38A

0.992

RBMX2

0.987

SNW1

0.987

MFAP3

0.974

MFAP2

0.974

SF3A3

0.961

SF3B2

0.958

SF3A2

0.957

BUD13

0.956

SART1

0.955

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BUD13	MFAP1	ENSP00000260210	ENSP00000267812	BUD13 homolog (S. cerevisiae)	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	0.956
BUD13	PRPF38A	ENSP00000260210	ENSP00000257181	BUD13 homolog (S. cerevisiae)	PRP38 pre-mRNA processing factor 38 (yeast) domain containing A; May be required for pre-mRNA splicing (Potential)	0.509
BUD13	RBMX2	ENSP00000260210	ENSP00000339090	BUD13 homolog (S. cerevisiae)	RNA binding motif protein, X-linked 2	0.999
BUD13	SART1	ENSP00000260210	ENSP00000310448	BUD13 homolog (S. cerevisiae)	squamous cell carcinoma antigen recognized by T cells; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA	0.947
BUD13	SF3A2	ENSP00000260210	ENSP00000221494	BUD13 homolog (S. cerevisiae)	splicing factor 3a, subunit 2, 66kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex	0.724
BUD13	SF3B2	ENSP00000260210	ENSP00000318861	BUD13 homolog (S. cerevisiae)	splicing factor 3b, subunit 2, 145kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron	0.974
MFAP1	BUD13	ENSP00000267812	ENSP00000260210	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	BUD13 homolog (S. cerevisiae)	0.956
MFAP1	MFAP2	ENSP00000267812	ENSP00000364685	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	microfibrillar-associated protein 2; Component of the elastin-associated microfibrils	0.974
MFAP1	MFAP3	ENSP00000267812	ENSP00000322956	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	microfibrillar-associated protein 3; Component of the elastin-associated microfibrils	0.974
MFAP1	PRPF38A	ENSP00000267812	ENSP00000257181	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	PRP38 pre-mRNA processing factor 38 (yeast) domain containing A; May be required for pre-mRNA splicing (Potential)	0.992
MFAP1	RBMX2	ENSP00000267812	ENSP00000339090	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	RNA binding motif protein, X-linked 2	0.987
MFAP1	SART1	ENSP00000267812	ENSP00000310448	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	squamous cell carcinoma antigen recognized by T cells; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA	0.955
MFAP1	SF3A2	ENSP00000267812	ENSP00000221494	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	splicing factor 3a, subunit 2, 66kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex	0.957
MFAP1	SF3A3	ENSP00000267812	ENSP00000362110	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	splicing factor 3a, subunit 3, 60kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex	0.961
MFAP1	SF3B2	ENSP00000267812	ENSP00000318861	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	splicing factor 3b, subunit 2, 145kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron	0.958
MFAP1	SNW1	ENSP00000267812	ENSP00000261531	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...]	0.987
MFAP2	MFAP1	ENSP00000364685	ENSP00000267812	microfibrillar-associated protein 2; Component of the elastin-associated microfibrils	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	0.974
MFAP2	MFAP3	ENSP00000364685	ENSP00000322956	microfibrillar-associated protein 2; Component of the elastin-associated microfibrils	microfibrillar-associated protein 3; Component of the elastin-associated microfibrils	0.985
MFAP3	MFAP1	ENSP00000322956	ENSP00000267812	microfibrillar-associated protein 3; Component of the elastin-associated microfibrils	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	0.974
MFAP3	MFAP2	ENSP00000322956	ENSP00000364685	microfibrillar-associated protein 3; Component of the elastin-associated microfibrils	microfibrillar-associated protein 2; Component of the elastin-associated microfibrils	0.985

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