DISP2 protein (Homo sapiens) - STRING network view

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DISP2

dispatched homolog 2 (Drosophila) (1401 aa)

Predicted Functional Partners:

GPC6

0.758

GPC4

0.758

GPC2

0.758

GPC1

0.758

SHH

0.692

BOC

0.686

CDON

0.686

PTCH1

0.674

IHH

0.642

KIF27

0.639

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOC	CDON	ENSP00000347546	ENSP00000263577	Boc homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	Cdon homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity)	0.650
BOC	DISP2	ENSP00000347546	ENSP00000267889	Boc homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	dispatched homolog 2 (Drosophila)	0.686
BOC	IHH	ENSP00000347546	ENSP00000295731	Boc homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity)	0.986
BOC	PTCH1	ENSP00000347546	ENSP00000332353	Boc homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	patched 1	0.762
BOC	SHH	ENSP00000347546	ENSP00000297261	Boc homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...]	0.991
CDON	BOC	ENSP00000263577	ENSP00000347546	Cdon homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity)	Boc homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	0.650
CDON	DISP2	ENSP00000263577	ENSP00000267889	Cdon homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity)	dispatched homolog 2 (Drosophila)	0.686
CDON	IHH	ENSP00000263577	ENSP00000295731	Cdon homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity)	Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity)	0.990
CDON	PTCH1	ENSP00000263577	ENSP00000332353	Cdon homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity)	patched 1	0.806
CDON	SHH	ENSP00000263577	ENSP00000297261	Cdon homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity)	sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...]	0.991
DISP2	BOC	ENSP00000267889	ENSP00000347546	dispatched homolog 2 (Drosophila)	Boc homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	0.686
DISP2	CDON	ENSP00000267889	ENSP00000263577	dispatched homolog 2 (Drosophila)	Cdon homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity)	0.686
DISP2	GPC1	ENSP00000267889	ENSP00000264039	dispatched homolog 2 (Drosophila)	glypican 1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-med [...]	0.758
DISP2	GPC2	ENSP00000267889	ENSP00000292377	dispatched homolog 2 (Drosophila)	glypican 2; Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity)	0.758
DISP2	GPC4	ENSP00000267889	ENSP00000359864	dispatched homolog 2 (Drosophila)	glypican 4; Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity)	0.758
DISP2	GPC6	ENSP00000267889	ENSP00000366246	dispatched homolog 2 (Drosophila)	glypican 6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling	0.758
DISP2	IHH	ENSP00000267889	ENSP00000295731	dispatched homolog 2 (Drosophila)	Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity)	0.642
DISP2	KIF27	ENSP00000267889	ENSP00000297814	dispatched homolog 2 (Drosophila)	kinesin family member 27; Plays an essential role in motile ciliogenesis (By similarity)	0.639
DISP2	PTCH1	ENSP00000267889	ENSP00000332353	dispatched homolog 2 (Drosophila)	patched 1	0.674
DISP2	SHH	ENSP00000267889	ENSP00000297261	dispatched homolog 2 (Drosophila)	sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...]	0.692

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