node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL2L14 | COMMD4 | ENSP00000309132 | ENSP00000267935 | BCL2-like 14 (apoptosis facilitator); Plays a role in apoptosis | COMM domain containing 4; Down-regulates activation of NF-kappa-B | 0.626 |
BCL2L14 | NME7 | ENSP00000309132 | ENSP00000356785 | BCL2-like 14 (apoptosis facilitator); Plays a role in apoptosis | NME/NM23 family member 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | 0.491 |
CDK19 | COMMD4 | ENSP00000357907 | ENSP00000267935 | cyclin-dependent kinase 19 | COMM domain containing 4; Down-regulates activation of NF-kappa-B | 0.644 |
COMMD1 | COMMD4 | ENSP00000308236 | ENSP00000267935 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | COMM domain containing 4; Down-regulates activation of NF-kappa-B | 0.618 |
COMMD1 | COMMD6 | ENSP00000308236 | ENSP00000348054 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | COMM domain containing 6; Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation | 0.979 |
COMMD1 | UBC | ENSP00000308236 | ENSP00000344818 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | ubiquitin C | 0.994 |
COMMD4 | BCL2L14 | ENSP00000267935 | ENSP00000309132 | COMM domain containing 4; Down-regulates activation of NF-kappa-B | BCL2-like 14 (apoptosis facilitator); Plays a role in apoptosis | 0.626 |
COMMD4 | CDK19 | ENSP00000267935 | ENSP00000357907 | COMM domain containing 4; Down-regulates activation of NF-kappa-B | cyclin-dependent kinase 19 | 0.644 |
COMMD4 | COMMD1 | ENSP00000267935 | ENSP00000308236 | COMM domain containing 4; Down-regulates activation of NF-kappa-B | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | 0.618 |
COMMD4 | COMMD6 | ENSP00000267935 | ENSP00000348054 | COMM domain containing 4; Down-regulates activation of NF-kappa-B | COMM domain containing 6; Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation | 0.815 |
COMMD4 | FAM86A | ENSP00000267935 | ENSP00000398502 | COMM domain containing 4; Down-regulates activation of NF-kappa-B | family with sequence similarity 86, member A | 0.700 |
COMMD4 | NME7 | ENSP00000267935 | ENSP00000356785 | COMM domain containing 4; Down-regulates activation of NF-kappa-B | NME/NM23 family member 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | 0.757 |
COMMD4 | TMA7 | ENSP00000267935 | ENSP00000397843 | COMM domain containing 4; Down-regulates activation of NF-kappa-B | translational machinery associated 7 homolog (S. cerevisiae) | 0.584 |
COMMD4 | TXNDC12 | ENSP00000267935 | ENSP00000360688 | COMM domain containing 4; Down-regulates activation of NF-kappa-B | thioredoxin domain containing 12 (endoplasmic reticulum); Possesses significant protein thiol-disulfide oxidase activity | 0.566 |
COMMD4 | UBC | ENSP00000267935 | ENSP00000344818 | COMM domain containing 4; Down-regulates activation of NF-kappa-B | ubiquitin C | 0.854 |
COMMD4 | ZDHHC16 | ENSP00000267935 | ENSP00000359891 | COMM domain containing 4; Down-regulates activation of NF-kappa-B | zinc finger, DHHC-type containing 16 | 0.640 |
COMMD6 | COMMD1 | ENSP00000348054 | ENSP00000308236 | COMM domain containing 6; Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | 0.979 |
COMMD6 | COMMD4 | ENSP00000348054 | ENSP00000267935 | COMM domain containing 6; Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation | COMM domain containing 4; Down-regulates activation of NF-kappa-B | 0.815 |
COMMD6 | UBC | ENSP00000348054 | ENSP00000344818 | COMM domain containing 6; Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation | ubiquitin C | 0.800 |
FAM86A | COMMD4 | ENSP00000398502 | ENSP00000267935 | family with sequence similarity 86, member A | COMM domain containing 4; Down-regulates activation of NF-kappa-B | 0.700 |