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STRINGSTRING
CDK19 CDK19 BCL2L14 BCL2L14 TMA7 TMA7 COMMD4 COMMD4 TXNDC12 TXNDC12 NME7 NME7 FAM86A FAM86A ZDHHC16 ZDHHC16 UBC UBC COMMD1 COMMD1 COMMD6 COMMD6
"COMMD4" - COMM domain containing 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Cooccurence
Coexpression
Experiments
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[Homology]
Score
COMMD4COMM domain containing 4; Down-regulates activation of NF-kappa-B (199 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.854
COMMD6
COMM domain containing 6; Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation (98 aa)
        score_image   score_image   0.815
NME7
NME/NM23 family member 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (376 aa)
            score_image   0.757
FAM86A
family with sequence similarity 86, member A (330 aa)
            score_image   0.700
CDK19
cyclin-dependent kinase 19 (502 aa)
        score_image       0.644
ZDHHC16
zinc finger, DHHC-type containing 16 (377 aa)
            score_image   0.640
BCL2L14
BCL2-like 14 (apoptosis facilitator); Plays a role in apoptosis (327 aa)
            score_image   0.626
COMMD1
copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes (190 aa)
        score_image   score_image   0.618
TMA7
translational machinery associated 7 homolog (S. cerevisiae) (64 aa)
            score_image   0.584
TXNDC12
thioredoxin domain containing 12 (endoplasmic reticulum); Possesses significant protein thiol-disulfide oxidase activity (172 aa)
            score_image   0.566
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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