MAN2C1 protein (Homo sapiens) - STRING network view

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MAN2C1

mannosidase, alpha, class 2C, member 1 (1040 aa)

Predicted Functional Partners:

EXOSC6

0.901

MAN2B1

0.888

POLR1C

0.848

PTEN

0.838

MAN2B2

0.819

BCL2

0.817

ENSG00000269242

0.800

MAN1B1

0.697

NXT2

0.651

NGLY1

0.626

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	MAN2C1	ENSP00000329623	ENSP00000267978	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	mannosidase, alpha, class 2C, member 1	0.817
BCL2	PTEN	ENSP00000329623	ENSP00000361021	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...]	0.975
ENSG00000269242	MAN2B2	ENSP00000470240	ENSP00000285599	annotation not available	mannosidase, alpha, class 2B, member 2	0.800
ENSG00000269242	MAN2C1	ENSP00000470240	ENSP00000267978	annotation not available	mannosidase, alpha, class 2C, member 1	0.800
EXOSC6	MAN2C1	ENSP00000398597	ENSP00000267978	exosome component 6; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The R [...]	mannosidase, alpha, class 2C, member 1	0.901
MAN1B1	MAN2B2	ENSP00000360645	ENSP00000285599	mannosidase, alpha, class 1B, member 1; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)	mannosidase, alpha, class 2B, member 2	0.450
MAN1B1	MAN2C1	ENSP00000360645	ENSP00000267978	mannosidase, alpha, class 1B, member 1; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)	mannosidase, alpha, class 2C, member 1	0.697
MAN2B1	MAN2C1	ENSP00000395473	ENSP00000267978	mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages	mannosidase, alpha, class 2C, member 1	0.888
MAN2B2	ENSG00000269242	ENSP00000285599	ENSP00000470240	mannosidase, alpha, class 2B, member 2	annotation not available	0.800
MAN2B2	MAN1B1	ENSP00000285599	ENSP00000360645	mannosidase, alpha, class 2B, member 2	mannosidase, alpha, class 1B, member 1; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)	0.450
MAN2B2	MAN2C1	ENSP00000285599	ENSP00000267978	mannosidase, alpha, class 2B, member 2	mannosidase, alpha, class 2C, member 1	0.819
MAN2C1	BCL2	ENSP00000267978	ENSP00000329623	mannosidase, alpha, class 2C, member 1	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	0.817
MAN2C1	ENSG00000269242	ENSP00000267978	ENSP00000470240	mannosidase, alpha, class 2C, member 1	annotation not available	0.800
MAN2C1	EXOSC6	ENSP00000267978	ENSP00000398597	mannosidase, alpha, class 2C, member 1	exosome component 6; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The R [...]	0.901
MAN2C1	MAN1B1	ENSP00000267978	ENSP00000360645	mannosidase, alpha, class 2C, member 1	mannosidase, alpha, class 1B, member 1; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)	0.697
MAN2C1	MAN2B1	ENSP00000267978	ENSP00000395473	mannosidase, alpha, class 2C, member 1	mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages	0.888
MAN2C1	MAN2B2	ENSP00000267978	ENSP00000285599	mannosidase, alpha, class 2C, member 1	mannosidase, alpha, class 2B, member 2	0.819
MAN2C1	NGLY1	ENSP00000267978	ENSP00000280700	mannosidase, alpha, class 2C, member 1	N-glycanase 1; Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for sub [...]	0.626
MAN2C1	NXT2	ENSP00000267978	ENSP00000218004	mannosidase, alpha, class 2C, member 1	nuclear transport factor 2-like export factor 2	0.651
MAN2C1	POLR1C	ENSP00000267978	ENSP00000361465	mannosidase, alpha, class 2C, member 1	polymerase (RNA) I polypeptide C, 30kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)	0.848

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