ADAMTS17 protein (Homo sapiens) - STRING network view

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ADAMTS17

ADAM metallopeptidase with thrombospondin type 1 motif, 17 (1095 aa)

Predicted Functional Partners:

FURIN

0.663

FBN1

0.610

LGI3

0.549

GOLGA6L9

0.472

CERS3

0.461

SCMH1

0.457

ANAPC13

0.450

AQP12B

0.412

MED21

0.411

CCDC137

0.407

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS17	ANAPC13	ENSP00000268070	ENSP00000346987	ADAM metallopeptidase with thrombospondin type 1 motif, 17	anaphase promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains	0.450
ADAMTS17	AQP12B	ENSP00000268070	ENSP00000384894	ADAM metallopeptidase with thrombospondin type 1 motif, 17	aquaporin 12B; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity)	0.412
ADAMTS17	CCDC137	ENSP00000268070	ENSP00000329360	ADAM metallopeptidase with thrombospondin type 1 motif, 17	coiled-coil domain containing 137	0.407
ADAMTS17	CERS3	ENSP00000268070	ENSP00000284382	ADAM metallopeptidase with thrombospondin type 1 motif, 17	ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity)	0.461
ADAMTS17	FBN1	ENSP00000268070	ENSP00000325527	ADAM metallopeptidase with thrombospondin type 1 motif, 17	fibrillin 1; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively	0.610
ADAMTS17	FURIN	ENSP00000268070	ENSP00000268171	ADAM metallopeptidase with thrombospondin type 1 motif, 17	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	0.663
ADAMTS17	GOLGA6L9	ENSP00000268070	ENSP00000300515	ADAM metallopeptidase with thrombospondin type 1 motif, 17	golgin A6 family-like 9	0.472
ADAMTS17	LGI3	ENSP00000268070	ENSP00000302297	ADAM metallopeptidase with thrombospondin type 1 motif, 17	leucine-rich repeat LGI family, member 3; May participate in the regulation of neuronal exocytosis (By similarity)	0.549
ADAMTS17	MED21	ENSP00000268070	ENSP00000282892	ADAM metallopeptidase with thrombospondin type 1 motif, 17	mediator complex subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors	0.411
ADAMTS17	SCMH1	ENSP00000268070	ENSP00000318094	ADAM metallopeptidase with thrombospondin type 1 motif, 17	sex comb on midleg homolog 1 (Drosophila); Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes (By similarity)	0.457
ANAPC13	ADAMTS17	ENSP00000346987	ENSP00000268070	anaphase promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains	ADAM metallopeptidase with thrombospondin type 1 motif, 17	0.450
ANAPC13	SCMH1	ENSP00000346987	ENSP00000318094	anaphase promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains	sex comb on midleg homolog 1 (Drosophila); Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes (By similarity)	0.426
AQP12B	ADAMTS17	ENSP00000384894	ENSP00000268070	aquaporin 12B; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity)	ADAM metallopeptidase with thrombospondin type 1 motif, 17	0.412
AQP12B	GOLGA6L9	ENSP00000384894	ENSP00000300515	aquaporin 12B; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity)	golgin A6 family-like 9	0.648
CCDC137	ADAMTS17	ENSP00000329360	ENSP00000268070	coiled-coil domain containing 137	ADAM metallopeptidase with thrombospondin type 1 motif, 17	0.407
CERS3	ADAMTS17	ENSP00000284382	ENSP00000268070	ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity)	ADAM metallopeptidase with thrombospondin type 1 motif, 17	0.461
FBN1	ADAMTS17	ENSP00000325527	ENSP00000268070	fibrillin 1; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively	ADAM metallopeptidase with thrombospondin type 1 motif, 17	0.610
FBN1	FURIN	ENSP00000325527	ENSP00000268171	fibrillin 1; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	0.938
FURIN	ADAMTS17	ENSP00000268171	ENSP00000268070	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	ADAM metallopeptidase with thrombospondin type 1 motif, 17	0.663
FURIN	FBN1	ENSP00000268171	ENSP00000325527	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	fibrillin 1; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively	0.938

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