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CACNA1I CACNA1I SLC35A1 SLC35A1 NCAM1 NCAM1 KCNH2 KCNH2 IL8 IL8 ST8SIA2 ST8SIA2 STX2 STX2 NPY NPY DNAJB11 DNAJB11 CREB1 CREB1 FEZ1 FEZ1
"ST8SIA2" - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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protein homology
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ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression (375 aa)    
Predicted Functional Partners:
NCAM1
neural cell adhesion molecule 1 (848 aa)
           score_image score_image   0.967
STX2
syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (288 aa)
             score_image   0.909
SLC35A1
solute carrier family 35 (CMP-sialic acid transporter), member A1; Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function (337 aa)
           score_image score_image   0.908
IL8
interleukin 8 (99 aa)
             score_image   0.872
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (358 aa)
             score_image   0.856
NPY
neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone (97 aa)
             score_image   0.823
CACNA1I
calcium channel, voltage-dependent, T type, alpha 1I subunit (2223 aa)
             score_image   0.822
CREB1
cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (341 aa)
             score_image   0.816
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 (1159 aa)
             score_image   0.814
FEZ1
fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules (392 aa)
             score_image   0.801
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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