node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFTUD1 | MRPL2 | ENSP00000268206 | ENSP00000373404 | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | mitochondrial ribosomal protein L2 | 0.970 |
EFTUD1 | MRPS5 | ENSP00000268206 | ENSP00000272418 | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | mitochondrial ribosomal protein S5 | 0.974 |
EFTUD1 | MRPS7 | ENSP00000268206 | ENSP00000245539 | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | mitochondrial ribosomal protein S7 | 0.974 |
EFTUD1 | RPL11 | ENSP00000268206 | ENSP00000363676 | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | ribosomal protein L11; Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity) | 0.981 |
EFTUD1 | RPL5 | ENSP00000268206 | ENSP00000359345 | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA | 0.980 |
EFTUD1 | RPL9 | ENSP00000268206 | ENSP00000346022 | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | ribosomal protein L9 | 0.973 |
EFTUD1 | RPS15A | ENSP00000268206 | ENSP00000318646 | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | ribosomal protein S15a | 0.972 |
EFTUD1 | RPS2 | ENSP00000268206 | ENSP00000341885 | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | ribosomal protein S2 | 0.974 |
EFTUD1 | RPS3 | ENSP00000268206 | ENSP00000433821 | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | ribosomal protein S3 | 0.977 |
EFTUD1 | RPS5 | ENSP00000268206 | ENSP00000196551 | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | ribosomal protein S5 | 0.974 |
MRPL2 | EFTUD1 | ENSP00000373404 | ENSP00000268206 | mitochondrial ribosomal protein L2 | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | 0.970 |
MRPL2 | MRPS5 | ENSP00000373404 | ENSP00000272418 | mitochondrial ribosomal protein L2 | mitochondrial ribosomal protein S5 | 0.993 |
MRPL2 | MRPS7 | ENSP00000373404 | ENSP00000245539 | mitochondrial ribosomal protein L2 | mitochondrial ribosomal protein S7 | 0.984 |
MRPL2 | RPL11 | ENSP00000373404 | ENSP00000363676 | mitochondrial ribosomal protein L2 | ribosomal protein L11; Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity) | 0.996 |
MRPL2 | RPL5 | ENSP00000373404 | ENSP00000359345 | mitochondrial ribosomal protein L2 | ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA | 0.996 |
MRPL2 | RPL9 | ENSP00000373404 | ENSP00000346022 | mitochondrial ribosomal protein L2 | ribosomal protein L9 | 0.996 |
MRPL2 | RPS15A | ENSP00000373404 | ENSP00000318646 | mitochondrial ribosomal protein L2 | ribosomal protein S15a | 0.987 |
MRPL2 | RPS2 | ENSP00000373404 | ENSP00000341885 | mitochondrial ribosomal protein L2 | ribosomal protein S2 | 0.992 |
MRPL2 | RPS3 | ENSP00000373404 | ENSP00000433821 | mitochondrial ribosomal protein L2 | ribosomal protein S3 | 0.993 |
MRPL2 | RPS5 | ENSP00000373404 | ENSP00000196551 | mitochondrial ribosomal protein L2 | ribosomal protein S5 | 0.978 |