SEPT12 protein (Homo sapiens) - STRING network view

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SEPT12

septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) (358 aa)

Predicted Functional Partners:

SEPT1

0.848

SEPT6

0.840

DNAJB13

0.718

C9orf69

0.645

SEPT14

0.637

SEPT10

0.633

SEPT11

0.631

SEPT8

0.630

SEPT5

0.625

BRSK2

0.623

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRSK2	SEPT1	ENSP00000310697	ENSP00000460441	BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...]	septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	0.587
BRSK2	SEPT10	ENSP00000310697	ENSP00000380824	BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...]	septin 10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential)	0.587
BRSK2	SEPT11	ENSP00000310697	ENSP00000264893	BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...]	septin 11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy	0.587
BRSK2	SEPT12	ENSP00000310697	ENSP00000268231	BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...]	septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	0.623
BRSK2	SEPT14	ENSP00000310697	ENSP00000373627	BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...]	septin 14; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	0.587
BRSK2	SEPT5	ENSP00000310697	ENSP00000391311	BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...]	septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity)	0.587
BRSK2	SEPT6	ENSP00000310697	ENSP00000341524	BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...]	septin 6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication	0.587
BRSK2	SEPT8	ENSP00000310697	ENSP00000367991	BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...]	septin 8; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion	0.587
C9orf69	SEPT12	ENSP00000453019	ENSP00000268231	chromosome 9 open reading frame 69; Plays a role in cell proliferation by promoting progression into S phase. Promotes human herpesvirus 1 (HHV-1) proliferation	septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	0.645
DNAJB13	SEPT1	ENSP00000344431	ENSP00000460441	DnaJ (Hsp40) homolog, subfamily B, member 13; May be involved in inhibiting testis spermatogenesis apoptosis	septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	0.733
DNAJB13	SEPT12	ENSP00000344431	ENSP00000268231	DnaJ (Hsp40) homolog, subfamily B, member 13; May be involved in inhibiting testis spermatogenesis apoptosis	septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	0.718
DNAJB13	SEPT5	ENSP00000344431	ENSP00000391311	DnaJ (Hsp40) homolog, subfamily B, member 13; May be involved in inhibiting testis spermatogenesis apoptosis	septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity)	0.678
SEPT1	BRSK2	ENSP00000460441	ENSP00000310697	septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...]	0.587
SEPT1	DNAJB13	ENSP00000460441	ENSP00000344431	septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	DnaJ (Hsp40) homolog, subfamily B, member 13; May be involved in inhibiting testis spermatogenesis apoptosis	0.733
SEPT1	SEPT10	ENSP00000460441	ENSP00000380824	septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	septin 10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential)	0.716
SEPT1	SEPT11	ENSP00000460441	ENSP00000264893	septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	septin 11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy	0.717
SEPT1	SEPT12	ENSP00000460441	ENSP00000268231	septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	0.848
SEPT1	SEPT14	ENSP00000460441	ENSP00000373627	septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	septin 14; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	0.869
SEPT1	SEPT5	ENSP00000460441	ENSP00000391311	septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity)	0.919
SEPT1	SEPT6	ENSP00000460441	ENSP00000341524	septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)	septin 6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication	0.972

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