node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARNT2 | CDR2 | ENSP00000307479 | ENSP00000268383 | aryl-hydrocarbon receptor nuclear translocator 2; Specifically recognizes the xenobiotic response element (XRE) | cerebellar degeneration-related protein 2, 62kDa | 0.691 |
CD8A | CDR2 | ENSP00000283635 | ENSP00000268383 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | cerebellar degeneration-related protein 2, 62kDa | 0.609 |
CD8A | MYC | ENSP00000283635 | ENSP00000367207 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.581 |
CD8A | UBC | ENSP00000283635 | ENSP00000344818 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | ubiquitin C | 0.859 |
CDR1 | CDR2 | ENSP00000359563 | ENSP00000268383 | cerebellar degeneration-related protein 1, 34kDa | cerebellar degeneration-related protein 2, 62kDa | 0.943 |
CDR1 | DUSP5 | ENSP00000359563 | ENSP00000358596 | cerebellar degeneration-related protein 1, 34kDa | dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1 | 0.589 |
CDR2 | ARNT2 | ENSP00000268383 | ENSP00000307479 | cerebellar degeneration-related protein 2, 62kDa | aryl-hydrocarbon receptor nuclear translocator 2; Specifically recognizes the xenobiotic response element (XRE) | 0.691 |
CDR2 | CD8A | ENSP00000268383 | ENSP00000283635 | cerebellar degeneration-related protein 2, 62kDa | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | 0.609 |
CDR2 | CDR1 | ENSP00000268383 | ENSP00000359563 | cerebellar degeneration-related protein 2, 62kDa | cerebellar degeneration-related protein 1, 34kDa | 0.943 |
CDR2 | DUSP5 | ENSP00000268383 | ENSP00000358596 | cerebellar degeneration-related protein 2, 62kDa | dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1 | 0.702 |
CDR2 | MORF4L2 | ENSP00000268383 | ENSP00000353643 | cerebellar degeneration-related protein 2, 62kDa | mortality factor 4 like 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senesce [...] | 0.588 |
CDR2 | MYC | ENSP00000268383 | ENSP00000367207 | cerebellar degeneration-related protein 2, 62kDa | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.966 |
CDR2 | NDN | ENSP00000268383 | ENSP00000332643 | cerebellar degeneration-related protein 2, 62kDa | necdin homolog (mouse); Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity) | 0.643 |
CDR2 | PIGV | ENSP00000268383 | ENSP00000078527 | cerebellar degeneration-related protein 2, 62kDa | phosphatidylinositol glycan anchor biosynthesis, class V; Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly | 0.592 |
CDR2 | PKN1 | ENSP00000268383 | ENSP00000343325 | cerebellar degeneration-related protein 2, 62kDa | protein kinase N1; PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates ’Ser-575’, ’Ser-637’ and ’Ser-669’ of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen r [...] | 0.936 |
CDR2 | UBC | ENSP00000268383 | ENSP00000344818 | cerebellar degeneration-related protein 2, 62kDa | ubiquitin C | 0.595 |
DUSP5 | CDR1 | ENSP00000358596 | ENSP00000359563 | dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1 | cerebellar degeneration-related protein 1, 34kDa | 0.589 |
DUSP5 | CDR2 | ENSP00000358596 | ENSP00000268383 | dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1 | cerebellar degeneration-related protein 2, 62kDa | 0.702 |
DUSP5 | UBC | ENSP00000358596 | ENSP00000344818 | dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1 | ubiquitin C | 0.717 |
MORF4L2 | CDR2 | ENSP00000353643 | ENSP00000268383 | mortality factor 4 like 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senesce [...] | cerebellar degeneration-related protein 2, 62kDa | 0.588 |