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STRINGSTRING
CDR1 CDR1 DUSP5 DUSP5 CD8A CD8A MYC MYC UBC UBC MORF4L2 MORF4L2 PKN1 PKN1 NDN NDN CDR2 CDR2 ARNT2 ARNT2 PIGV PIGV
"CDR2" - cerebellar degeneration-related protein 2, 62kDa in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
CDR2cerebellar degeneration-related protein 2, 62kDa (454 aa)    
Predicted Functional Partners:
MYC
v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes (454 aa)
        score_image   score_image   0.966
CDR1
cerebellar degeneration-related protein 1, 34kDa (262 aa)
            score_image   0.943
PKN1
protein kinase N1; PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates ’Ser-575’, ’Ser-637’ and ’Ser-669’ of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen r [...] (948 aa)
        score_image   score_image   0.936
DUSP5
dual specificity phosphatase 5; Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1 (384 aa)
            score_image   0.702
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2; Specifically recognizes the xenobiotic response element (XRE) (717 aa)
        score_image       0.691
NDN
necdin homolog (mouse); Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity) (321 aa)
        score_image   score_image   0.643
CD8A
CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains (235 aa)
            score_image   0.609
UBC
ubiquitin C (685 aa)
        score_image       0.595
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V; Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (493 aa)
            score_image   0.592
MORF4L2
mortality factor 4 like 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senesce [...] (288 aa)
        score_image   score_image   0.588
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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