Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | CMTM2 | CKLF-like MARVEL transmembrane domain containing 2 (248 aa) | ||||||||||||
Predicted Functional Partners:
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 | KLK3 | kallikrein-related peptidase 3; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum (261 aa) |
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0.900 | ||||||||||
 | CMTM3 | CKLF-like MARVEL transmembrane domain containing 3 (182 aa) |
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0.868 | ||||||||||
 | CMTM1 | CKLF-like MARVEL transmembrane domain containing 1 (286 aa) |
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0.867 | ||||||||||
 | CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 (234 aa) |
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0.867 | ||||||||||
 | CKLF | chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10 (152 aa) |
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0.860 | ||||||||||
 | CMTM7 | CKLF-like MARVEL transmembrane domain containing 7 (175 aa) |
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0.811 | ||||||||||
 | GATA1 | GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells (413 aa) |
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0.698 | ||||||||||
 | NR4A1 | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 (611 aa) |
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0.692 | ||||||||||
 | CMTM5 | CKLF-like MARVEL transmembrane domain containing 5 (156 aa) |
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0.515 | ||||||||||
 | CKLF-CMTM1 | CKLF-CMTM1 readthrough (115 aa) |
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0.509 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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