| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARC | ETNK2 | ENSP00000349022 | ENSP00000356170 | activity-regulated cytoskeleton-associated protein; Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration | ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity) | 0.692 |
| ARC | NOL3 | ENSP00000349022 | ENSP00000268605 | activity-regulated cytoskeleton-associated protein; Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | 0.875 |
| ARC | SIRPA | ENSP00000349022 | ENSP00000348307 | activity-regulated cytoskeleton-associated protein; Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration | signal-regulatory protein alpha | 0.692 |
| CASP8 | FADD | ENSP00000351273 | ENSP00000301838 | caspase 8, apoptosis-related cysteine peptidase | Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling | 0.999 |
| CASP8 | NOL3 | ENSP00000351273 | ENSP00000268605 | caspase 8, apoptosis-related cysteine peptidase | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | 0.846 |
| ETNK2 | ARC | ENSP00000356170 | ENSP00000349022 | ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity) | activity-regulated cytoskeleton-associated protein; Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration | 0.692 |
| ETNK2 | NOL3 | ENSP00000356170 | ENSP00000268605 | ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity) | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | 0.692 |
| FADD | CASP8 | ENSP00000301838 | ENSP00000351273 | Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling | caspase 8, apoptosis-related cysteine peptidase | 0.999 |
| FADD | NOL3 | ENSP00000301838 | ENSP00000268605 | Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | 0.805 |
| NOL3 | ARC | ENSP00000268605 | ENSP00000349022 | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | activity-regulated cytoskeleton-associated protein; Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration | 0.875 |
| NOL3 | CASP8 | ENSP00000268605 | ENSP00000351273 | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | caspase 8, apoptosis-related cysteine peptidase | 0.846 |
| NOL3 | ETNK2 | ENSP00000268605 | ENSP00000356170 | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity) | 0.692 |
| NOL3 | FADD | ENSP00000268605 | ENSP00000301838 | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling | 0.805 |
| NOL3 | OPRL1 | ENSP00000268605 | ENSP00000336764 | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | opiate receptor-like 1; Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase | 0.700 |
| NOL3 | PDS5A | ENSP00000268605 | ENSP00000303427 | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae); Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair | 0.691 |
| NOL3 | PDS5B | ENSP00000268605 | ENSP00000313851 | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae); Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells | 0.691 |
| NOL3 | PNOC | ENSP00000268605 | ENSP00000301908 | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | prepronociceptin; Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development (By similarity) | 0.873 |
| NOL3 | SIRPA | ENSP00000268605 | ENSP00000348307 | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | signal-regulatory protein alpha | 0.701 |
| NOL3 | SRSF9 | ENSP00000268605 | ENSP00000229390 | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | serine/arginine-rich splicing factor 9; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 | 0.940 |
| OPRL1 | NOL3 | ENSP00000336764 | ENSP00000268605 | opiate receptor-like 1; Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase | nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing | 0.700 |
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