GAS8 protein (Homo sapiens) - STRING network view

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GAS8

growth arrest-specific 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity) (478 aa)

Predicted Functional Partners:

C16orf3

0.910

MYH14

0.800

SMO

0.782

ZNF276

0.721

DNALI1

0.622

CCDC65

0.550

TRMT11

0.530

CCDC164

0.513

CCDC39

0.506

C22orf28

0.457

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C16orf3	GAS8	ENSP00000386218	ENSP00000268699	chromosome 16 open reading frame 3	growth arrest-specific 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity)	0.910
C22orf28	GAS8	ENSP00000216038	ENSP00000268699	chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs	growth arrest-specific 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity)	0.457
C22orf28	TRMT11	ENSP00000216038	ENSP00000333934	chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs	tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity)	0.585
CCDC164	CCDC39	ENSP00000288710	ENSP00000405708	coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	0.758
CCDC164	CCDC65	ENSP00000288710	ENSP00000312706	coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending	coiled-coil domain containing 65	0.828
CCDC164	GAS8	ENSP00000288710	ENSP00000268699	coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending	growth arrest-specific 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity)	0.513
CCDC39	CCDC164	ENSP00000405708	ENSP00000288710	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending	0.758
CCDC39	CCDC65	ENSP00000405708	ENSP00000312706	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	coiled-coil domain containing 65	0.816
CCDC39	DNALI1	ENSP00000405708	ENSP00000296218	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	dynein, axonemal, light intermediate chain 1; May play a dynamic role in flagellar motility	0.469
CCDC39	GAS8	ENSP00000405708	ENSP00000268699	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	growth arrest-specific 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity)	0.506
CCDC65	CCDC164	ENSP00000312706	ENSP00000288710	coiled-coil domain containing 65	coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending	0.828
CCDC65	CCDC39	ENSP00000312706	ENSP00000405708	coiled-coil domain containing 65	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	0.816
CCDC65	GAS8	ENSP00000312706	ENSP00000268699	coiled-coil domain containing 65	growth arrest-specific 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity)	0.550
DNALI1	CCDC39	ENSP00000296218	ENSP00000405708	dynein, axonemal, light intermediate chain 1; May play a dynamic role in flagellar motility	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	0.469
DNALI1	GAS8	ENSP00000296218	ENSP00000268699	dynein, axonemal, light intermediate chain 1; May play a dynamic role in flagellar motility	growth arrest-specific 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity)	0.622
GAS8	C16orf3	ENSP00000268699	ENSP00000386218	growth arrest-specific 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity)	chromosome 16 open reading frame 3	0.910
GAS8	C22orf28	ENSP00000268699	ENSP00000216038	growth arrest-specific 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity)	chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs	0.457
GAS8	CCDC164	ENSP00000268699	ENSP00000288710	growth arrest-specific 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity)	coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending	0.513
GAS8	CCDC39	ENSP00000268699	ENSP00000405708	growth arrest-specific 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity)	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	0.506
GAS8	CCDC65	ENSP00000268699	ENSP00000312706	growth arrest-specific 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity)	coiled-coil domain containing 65	0.550

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