Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | CPNE7 | copine VII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) (633 aa) | ||||||||||||
Predicted Functional Partners:
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 | OTUB1 | OTU domain, ubiquitin aldehyde binding 1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes a [...] (271 aa) |
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0.748 | |||||||||
 | USP53 | ubiquitin specific peptidase 53; Has no peptidase activity (1073 aa) |
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0.742 | |||||||||
 | ARHGEF17 | Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases (2063 aa) |
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0.652 | ||||||||||
 | UVRAG | UV radiation resistance associated (699 aa) |
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0.592 | ||||||||||
 | DENND6B | DENN/MADD domain containing 6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35 (585 aa) |
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0.544 | ||||||||||
 | RSG1 | REM2 and RAB-like small GTPase 1; Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity) (258 aa) |
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0.435 | ||||||||||
 | RAP2A | RAP2A, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (183 aa) |
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0.429 | ||||||||||
 | DIRAS2 | DIRAS family, GTP-binding RAS-like 2; Displays low GTPase activity and exist predominantly in the GTP-bound form (199 aa) |
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0.426 | ||||||||||
 | DIRAS3 | DIRAS family, GTP-binding RAS-like 3 (229 aa) |
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0.426 | ||||||||||
 | NRAS | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa) |
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0.426 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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