node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AURKB | BUB1B | ENSP00000463999 | ENSP00000287598 | aurora kinase B | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 0.999 |
AURKB | CASC5 | ENSP00000463999 | ENSP00000335463 | aurora kinase B | cancer susceptibility candidate 5; Performs two crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore | 0.959 |
AURKB | CKAP5 | ENSP00000463999 | ENSP00000432768 | aurora kinase B | cytoskeleton associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles | 0.970 |
AURKB | CLASP1 | ENSP00000463999 | ENSP00000263710 | aurora kinase B | cytoplasmic linker associated protein 1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is re [...] | 0.927 |
AURKB | KIF2B | ENSP00000463999 | ENSP00000268919 | aurora kinase B | kinesin family member 2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity | 0.976 |
AURKB | MAPRE1 | ENSP00000463999 | ENSP00000364721 | aurora kinase B | microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration | 0.999 |
AURKB | NDC80 | ENSP00000463999 | ENSP00000261597 | aurora kinase B | NDC80 kinetochore complex component homolog (S. cerevisiae); Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore | 0.999 |
AURKB | PLK1 | ENSP00000463999 | ENSP00000300093 | aurora kinase B | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | 0.954 |
AURKB | SGOL2 | ENSP00000463999 | ENSP00000350447 | aurora kinase B | shugoshin-like 2 (S. pombe); Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Ess [...] | 0.989 |
AURKB | ZW10 | ENSP00000463999 | ENSP00000200135 | aurora kinase B | ZW10, kinetochore associated, homolog (Drosophila); Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum | 0.954 |
BUB1B | AURKB | ENSP00000287598 | ENSP00000463999 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | aurora kinase B | 0.999 |
BUB1B | CASC5 | ENSP00000287598 | ENSP00000335463 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | cancer susceptibility candidate 5; Performs two crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore | 0.999 |
BUB1B | CKAP5 | ENSP00000287598 | ENSP00000432768 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | cytoskeleton associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles | 0.938 |
BUB1B | CLASP1 | ENSP00000287598 | ENSP00000263710 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | cytoplasmic linker associated protein 1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is re [...] | 0.972 |
BUB1B | KIF2B | ENSP00000287598 | ENSP00000268919 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | kinesin family member 2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity | 0.953 |
BUB1B | MAPRE1 | ENSP00000287598 | ENSP00000364721 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration | 0.976 |
BUB1B | NDC80 | ENSP00000287598 | ENSP00000261597 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | NDC80 kinetochore complex component homolog (S. cerevisiae); Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore | 0.980 |
BUB1B | PLK1 | ENSP00000287598 | ENSP00000300093 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | 0.999 |
BUB1B | SGOL2 | ENSP00000287598 | ENSP00000350447 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | shugoshin-like 2 (S. pombe); Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Ess [...] | 0.950 |
BUB1B | ZW10 | ENSP00000287598 | ENSP00000200135 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | ZW10, kinetochore associated, homolog (Drosophila); Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum | 0.990 |