LRRC46 protein (Homo sapiens) - STRING network view

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LRRC46

leucine rich repeat containing 46 (321 aa)

Predicted Functional Partners:

ASCC2

0.771

TMED4

0.556

MYO1G

0.556

PPP1R11

0.553

POTEE

0.526

POTEI

0.526

POTEJ

0.526

POTEF

0.526

IGBP1

0.523

ACIN1

0.512

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACIN1	ASCC2	ENSP00000262710	ENSP00000305502	apoptotic chromatin condensation inducer 1; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells	activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation	0.455
ACIN1	LRRC46	ENSP00000262710	ENSP00000269025	apoptotic chromatin condensation inducer 1; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells	leucine rich repeat containing 46	0.512
ASCC2	ACIN1	ENSP00000305502	ENSP00000262710	activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation	apoptotic chromatin condensation inducer 1; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells	0.455
ASCC2	IGBP1	ENSP00000305502	ENSP00000348784	activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation	immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits	0.491
ASCC2	LRRC46	ENSP00000305502	ENSP00000269025	activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation	leucine rich repeat containing 46	0.771
ASCC2	MYO1G	ENSP00000305502	ENSP00000258787	activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation	myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)	0.494
ASCC2	TMED4	ENSP00000305502	ENSP00000404042	activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation	transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity)	0.559
IGBP1	ASCC2	ENSP00000348784	ENSP00000305502	immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits	activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation	0.491
IGBP1	LRRC46	ENSP00000348784	ENSP00000269025	immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits	leucine rich repeat containing 46	0.523
LRRC46	ACIN1	ENSP00000269025	ENSP00000262710	leucine rich repeat containing 46	apoptotic chromatin condensation inducer 1; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells	0.512
LRRC46	ASCC2	ENSP00000269025	ENSP00000305502	leucine rich repeat containing 46	activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation	0.771
LRRC46	IGBP1	ENSP00000269025	ENSP00000348784	leucine rich repeat containing 46	immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits	0.523
LRRC46	MYO1G	ENSP00000269025	ENSP00000258787	leucine rich repeat containing 46	myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)	0.556
LRRC46	POTEE	ENSP00000269025	ENSP00000439189	leucine rich repeat containing 46	POTE ankyrin domain family member E	0.526
LRRC46	POTEF	ENSP00000269025	ENSP00000350052	leucine rich repeat containing 46	POTE ankyrin domain family, member F	0.526
LRRC46	POTEI	ENSP00000269025	ENSP00000392718	leucine rich repeat containing 46	POTE ankyrin domain family, member I	0.526
LRRC46	POTEJ	ENSP00000269025	ENSP00000387176	leucine rich repeat containing 46	POTE ankyrin domain family, member J	0.526
LRRC46	PPP1R11	ENSP00000269025	ENSP00000365963	leucine rich repeat containing 46	protein phosphatase 1, regulatory (inhibitor) subunit 11	0.553
LRRC46	TMED4	ENSP00000269025	ENSP00000404042	leucine rich repeat containing 46	transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity)	0.556
MYO1G	ASCC2	ENSP00000258787	ENSP00000305502	myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)	activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation	0.494

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