TAF4B protein (Homo sapiens) - STRING network view

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TAF4B

TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa; Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of [...] (862 aa)

Predicted Functional Partners:

TAF1

0.997

TBP

0.997

TAF12

0.997

TAF6

0.992

TAF10

0.991

TAF13

0.991

TAF11

0.990

TAF5

0.989

TAF1L

0.966

GTF2B

0.957

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GTF2B	TAF1	ENSP00000359531	ENSP00000276072	general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.996
GTF2B	TAF10	ENSP00000359531	ENSP00000299424	general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors	0.990
GTF2B	TAF11	ENSP00000359531	ENSP00000354633	general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa; Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively)	0.997
GTF2B	TAF12	ENSP00000359531	ENSP00000263974	general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription	0.979
GTF2B	TAF13	ENSP00000359531	ENSP00000355051	general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa; TFIID beta-specific TAFII	0.965
GTF2B	TAF1L	ENSP00000359531	ENSP00000418379	general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced	0.906
GTF2B	TAF4B	ENSP00000359531	ENSP00000269142	general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa; Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of [...]	0.957
GTF2B	TAF5	ENSP00000359531	ENSP00000358854	general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, a [...]	0.973
GTF2B	TAF6	ENSP00000359531	ENSP00000399982	general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors	0.996
GTF2B	TBP	ENSP00000359531	ENSP00000230354	general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II	TATA box binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 wi [...]	0.999
TAF1	GTF2B	ENSP00000276072	ENSP00000359531	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II	0.996
TAF1	TAF10	ENSP00000276072	ENSP00000299424	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors	0.999
TAF1	TAF11	ENSP00000276072	ENSP00000354633	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa; Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively)	0.999
TAF1	TAF12	ENSP00000276072	ENSP00000263974	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription	0.999
TAF1	TAF13	ENSP00000276072	ENSP00000355051	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa; TFIID beta-specific TAFII	0.998
TAF1	TAF1L	ENSP00000276072	ENSP00000418379	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced	0.718
TAF1	TAF4B	ENSP00000276072	ENSP00000269142	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa; Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of [...]	0.997
TAF1	TAF5	ENSP00000276072	ENSP00000358854	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, a [...]	0.999
TAF1	TAF6	ENSP00000276072	ENSP00000399982	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors	0.999
TAF1	TBP	ENSP00000276072	ENSP00000230354	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	TATA box binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 wi [...]	0.999

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