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HSPA9 HSPA9 USP50 USP50 CLN3 CLN3 PHB2 PHB2 UBC UBC AFG3L2 AFG3L2 PHB PHB LONP1 LONP1 YME1L1 YME1L1 OMA1 OMA1 LONP2 LONP2
"AFG3L2" - AFG3 ATPase family member 3-like 2 (S. cerevisiae) in Homo sapiens
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protein of unknown 3D structure
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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AFG3L2AFG3 ATPase family member 3-like 2 (S. cerevisiae); ATP-dependent protease which is essential for axonal development (By similarity) (797 aa)    
Predicted Functional Partners:
PHB
prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (272 aa)
      score_image score_image   score_image   0.883
PHB2
prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (299 aa)
      score_image score_image   score_image   0.809
LONP1
lon peptidase 1, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single- stranded, site-specific, and strand-specific manner. May regulate mitocho [...] (959 aa)
      score_image score_image   score_image   0.784
OMA1
OMA1 zinc metallopeptidase homolog (S. cerevisiae); Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (524 aa)
        score_image   score_image   0.777
HSPA9
heat shock 70kDa protein 9 (mortalin) (679 aa)
      score_image score_image   score_image   0.757
UBC
ubiquitin C (685 aa)
        score_image       0.752
USP50
ubiquitin specific peptidase 50; Has no peptidase activity (334 aa)
        score_image       0.740
LONP2
lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1 (852 aa)
      score_image score_image   score_image   0.720
CLN3
ceroid-lipofuscinosis, neuronal 3 (438 aa)
        score_image       0.704
YME1L1
YME1-like 1 (S. cerevisiae); Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1 (773 aa)
    score_image score_image score_image   score_image score_image 0.701
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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