node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABP1 | AGMAT | ENSP00000354193 | ENSP00000364986 | amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function | agmatine ureohydrolase (agmatinase) | 0.900 |
ABP1 | ODC1 | ENSP00000354193 | ENSP00000234111 | amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function | ornithine decarboxylase 1 | 0.901 |
ABP1 | SAT2 | ENSP00000354193 | ENSP00000269298 | amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function | spermidine/spermine N1-acetyltransferase family member 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine | 0.900 |
ABP1 | SRM | ENSP00000354193 | ENSP00000366156 | amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function | spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine | 0.900 |
AGMAT | ABP1 | ENSP00000364986 | ENSP00000354193 | agmatine ureohydrolase (agmatinase) | amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function | 0.900 |
AGMAT | ODC1 | ENSP00000364986 | ENSP00000234111 | agmatine ureohydrolase (agmatinase) | ornithine decarboxylase 1 | 0.965 |
AGMAT | SAT2 | ENSP00000364986 | ENSP00000269298 | agmatine ureohydrolase (agmatinase) | spermidine/spermine N1-acetyltransferase family member 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine | 0.900 |
AGMAT | SRM | ENSP00000364986 | ENSP00000366156 | agmatine ureohydrolase (agmatinase) | spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine | 0.980 |
GLYATL1 | PAOX | ENSP00000300079 | ENSP00000278060 | glycine-N-acyltransferase-like 1; Acyltransferase which transfers an acyl group to the N- terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor | polyamine oxidase (exo-N4-amino) | 0.755 |
GLYATL1 | SAT2 | ENSP00000300079 | ENSP00000269298 | glycine-N-acyltransferase-like 1; Acyltransferase which transfers an acyl group to the N- terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor | spermidine/spermine N1-acetyltransferase family member 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine | 0.750 |
HIF1A | SAT2 | ENSP00000338018 | ENSP00000269298 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] | spermidine/spermine N1-acetyltransferase family member 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine | 0.943 |
HIF1A | TCEB1 | ENSP00000338018 | ENSP00000284811 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | 0.999 |
MAOA | PAOX | ENSP00000340684 | ENSP00000278060 | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | polyamine oxidase (exo-N4-amino) | 0.663 |
MAOA | SAT2 | ENSP00000340684 | ENSP00000269298 | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | spermidine/spermine N1-acetyltransferase family member 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine | 0.900 |
MAOB | SAT2 | ENSP00000367309 | ENSP00000269298 | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | spermidine/spermine N1-acetyltransferase family member 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine | 0.900 |
ODC1 | ABP1 | ENSP00000234111 | ENSP00000354193 | ornithine decarboxylase 1 | amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function | 0.901 |
ODC1 | AGMAT | ENSP00000234111 | ENSP00000364986 | ornithine decarboxylase 1 | agmatine ureohydrolase (agmatinase) | 0.965 |
ODC1 | PAOX | ENSP00000234111 | ENSP00000278060 | ornithine decarboxylase 1 | polyamine oxidase (exo-N4-amino) | 0.502 |
ODC1 | SAT2 | ENSP00000234111 | ENSP00000269298 | ornithine decarboxylase 1 | spermidine/spermine N1-acetyltransferase family member 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine | 0.907 |
ODC1 | SRM | ENSP00000234111 | ENSP00000366156 | ornithine decarboxylase 1 | spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine | 0.989 |