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MAOA MAOA AGMAT AGMAT MAOB MAOB SRM SRM PAOX PAOX ABP1 ABP1 ODC1 ODC1 SAT2 SAT2 HIF1A HIF1A GLYATL1 GLYATL1 TCEB1 TCEB1
"SAT2" - spermidine/spermine N1-acetyltransferase family member 2 in Homo sapiens
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protein of unknown 3D structure
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second shell of interactors
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experimentally determined
Predicted Interactions
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protein homology
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Score
SAT2spermidine/spermine N1-acetyltransferase family member 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine (170 aa)    
Predicted Functional Partners:
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] (826 aa)
        score_image   score_image   0.943
SRM
spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine (302 aa)
          score_image score_image   0.912
ODC1
ornithine decarboxylase 1 (461 aa)
          score_image score_image   0.907
MAOB
monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (520 aa)
          score_image     0.900
AGMAT
agmatine ureohydrolase (agmatinase) (352 aa)
          score_image     0.900
ABP1
amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function (751 aa)
          score_image     0.900
MAOA
monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (527 aa)
          score_image     0.900
TCEB1
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (112 aa)
        score_image   score_image   0.850
PAOX
polyamine oxidase (exo-N4-amino) (511 aa)
            score_image   0.815
GLYATL1
glycine-N-acyltransferase-like 1; Acyltransferase which transfers an acyl group to the N- terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor (333 aa)
            score_image   0.750
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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