node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTBP2 | ZNF750 | ENSP00000311825 | ENSP00000269394 | C-terminal binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity) | zinc finger protein 750; Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation- acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression | 0.508 |
DOC2B | RNMTL1 | ENSP00000343665 | ENSP00000306080 | double C2-like domains, beta; Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes [...] | RNA methyltransferase like 1; Probable RNA methyltransferase (By similarity) | 0.507 |
DOC2B | ZNF750 | ENSP00000343665 | ENSP00000269394 | double C2-like domains, beta; Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes [...] | zinc finger protein 750; Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation- acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression | 0.460 |
FN3K | RNMTL1 | ENSP00000300784 | ENSP00000306080 | fructosamine 3 kinase; May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme | RNA methyltransferase like 1; Probable RNA methyltransferase (By similarity) | 0.505 |
FN3K | ZNF750 | ENSP00000300784 | ENSP00000269394 | fructosamine 3 kinase; May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme | zinc finger protein 750; Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation- acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression | 0.468 |
FN3KRP | METRNL | ENSP00000269373 | ENSP00000315731 | fructosamine 3 kinase related protein; Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein- bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation | meteorin, glial cell differentiation regulator-like | 0.420 |
FN3KRP | RNMTL1 | ENSP00000269373 | ENSP00000306080 | fructosamine 3 kinase related protein; Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein- bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation | RNA methyltransferase like 1; Probable RNA methyltransferase (By similarity) | 0.579 |
FN3KRP | TBCD | ENSP00000269373 | ENSP00000347719 | fructosamine 3 kinase related protein; Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein- bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation | tubulin folding cofactor D | 0.407 |
FN3KRP | ZNF750 | ENSP00000269373 | ENSP00000269394 | fructosamine 3 kinase related protein; Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein- bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation | zinc finger protein 750; Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation- acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression | 0.530 |
FOXK2 | RNMTL1 | ENSP00000335677 | ENSP00000306080 | forkhead box K2; Recognizes the core sequence 5’-TAAACA-3’. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements | RNA methyltransferase like 1; Probable RNA methyltransferase (By similarity) | 0.469 |
FOXK2 | ZNF750 | ENSP00000335677 | ENSP00000269394 | forkhead box K2; Recognizes the core sequence 5’-TAAACA-3’. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements | zinc finger protein 750; Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation- acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression | 0.442 |
METRNL | FN3KRP | ENSP00000315731 | ENSP00000269373 | meteorin, glial cell differentiation regulator-like | fructosamine 3 kinase related protein; Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein- bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation | 0.420 |
METRNL | RNMTL1 | ENSP00000315731 | ENSP00000306080 | meteorin, glial cell differentiation regulator-like | RNA methyltransferase like 1; Probable RNA methyltransferase (By similarity) | 0.580 |
METRNL | ZNF750 | ENSP00000315731 | ENSP00000269394 | meteorin, glial cell differentiation regulator-like | zinc finger protein 750; Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation- acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression | 0.538 |
NXN | RNMTL1 | ENSP00000337443 | ENSP00000306080 | nucleoredoxin; Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity) | RNA methyltransferase like 1; Probable RNA methyltransferase (By similarity) | 0.435 |
NXN | ZNF750 | ENSP00000337443 | ENSP00000269394 | nucleoredoxin; Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity) | zinc finger protein 750; Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation- acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression | 0.440 |
OFD1 | ZNF750 | ENSP00000344314 | ENSP00000269394 | oral-facial-digital syndrome 1; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis (By similarity) | zinc finger protein 750; Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation- acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression | 0.506 |
RNMTL1 | DOC2B | ENSP00000306080 | ENSP00000343665 | RNA methyltransferase like 1; Probable RNA methyltransferase (By similarity) | double C2-like domains, beta; Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes [...] | 0.507 |
RNMTL1 | FN3K | ENSP00000306080 | ENSP00000300784 | RNA methyltransferase like 1; Probable RNA methyltransferase (By similarity) | fructosamine 3 kinase; May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme | 0.505 |
RNMTL1 | FN3KRP | ENSP00000306080 | ENSP00000269373 | RNA methyltransferase like 1; Probable RNA methyltransferase (By similarity) | fructosamine 3 kinase related protein; Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein- bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation | 0.579 |