ELAC1 protein (Homo sapiens) - STRING network view

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ELAC1

elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA (363 aa)

Predicted Functional Partners:

TBL3

0.707

RRP12

0.700

ENDOG

0.666

EXOG

0.666

RAB3D

0.658

CPSF3

0.635

NOP14

0.630

MEX3C

0.575

DCLRE1A

0.569

TSR1

0.535

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPSF3	DCLRE1A	ENSP00000238112	ENSP00000355185	cleavage and polyadenylation specific factor 3, 73kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3’-end-processing endonuclease. Also involved in the histone 3’-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3’-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5’ to 3’ [...]	DNA cross-link repair 1A; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons	0.811
CPSF3	ELAC1	ENSP00000238112	ENSP00000269466	cleavage and polyadenylation specific factor 3, 73kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3’-end-processing endonuclease. Also involved in the histone 3’-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3’-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5’ to 3’ [...]	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	0.635
DCLRE1A	CPSF3	ENSP00000355185	ENSP00000238112	DNA cross-link repair 1A; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons	cleavage and polyadenylation specific factor 3, 73kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3’-end-processing endonuclease. Also involved in the histone 3’-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3’-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5’ to 3’ [...]	0.811
DCLRE1A	ELAC1	ENSP00000355185	ENSP00000269466	DNA cross-link repair 1A; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	0.569
ELAC1	CPSF3	ENSP00000269466	ENSP00000238112	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	cleavage and polyadenylation specific factor 3, 73kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3’-end-processing endonuclease. Also involved in the histone 3’-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3’-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5’ to 3’ [...]	0.635
ELAC1	DCLRE1A	ENSP00000269466	ENSP00000355185	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	DNA cross-link repair 1A; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons	0.569
ELAC1	ENDOG	ENSP00000269466	ENSP00000361725	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	endonuclease G; Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity)	0.666
ELAC1	EXOG	ENSP00000269466	ENSP00000287675	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	endo/exonuclease (5’-3’), endonuclease G-like; Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single stranded DNA and 5’-3’ exonuclease activity	0.666
ELAC1	MEX3C	ENSP00000269466	ENSP00000385610	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	mex-3 homolog C (C. elegans); E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3’ UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation	0.575
ELAC1	NOP14	ENSP00000269466	ENSP00000315674	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	NOP14 nucleolar protein homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity)	0.630
ELAC1	RAB3D	ENSP00000269466	ENSP00000222120	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity)	0.658
ELAC1	RRP12	ENSP00000269466	ENSP00000360031	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	ribosomal RNA processing 12 homolog (S. cerevisiae)	0.700
ELAC1	TBL3	ENSP00000269466	ENSP00000454836	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	transducin (beta)-like 3	0.707
ELAC1	TSR1	ENSP00000269466	ENSP00000301364	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	0.535
ENDOG	ELAC1	ENSP00000361725	ENSP00000269466	endonuclease G; Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity)	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	0.666
EXOG	ELAC1	ENSP00000287675	ENSP00000269466	endo/exonuclease (5’-3’), endonuclease G-like; Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single stranded DNA and 5’-3’ exonuclease activity	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	0.666
MEX3C	ELAC1	ENSP00000385610	ENSP00000269466	mex-3 homolog C (C. elegans); E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3’ UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	0.575
NOP14	ELAC1	ENSP00000315674	ENSP00000269466	NOP14 nucleolar protein homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity)	elaC homolog 1 (E. coli); Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA	0.630
NOP14	RRP12	ENSP00000315674	ENSP00000360031	NOP14 nucleolar protein homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity)	ribosomal RNA processing 12 homolog (S. cerevisiae)	0.996
NOP14	TBL3	ENSP00000315674	ENSP00000454836	NOP14 nucleolar protein homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity)	transducin (beta)-like 3	0.991

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