node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | ARL5C | ENSP00000253792 | ENSP00000269586 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | ADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) | 0.621 |
ARFGAP2 | ARL5C | ENSP00000434442 | ENSP00000269586 | ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | ADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) | 0.615 |
ARFGAP2 | ENSG00000262633 | ENSP00000434442 | ENSP00000461460 | ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | Golgi SNAP receptor complex member 2; Uncharacterized protein | 0.767 |
ARFGAP2 | GBF1 | ENSP00000434442 | ENSP00000359000 | ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | golgi brefeldin A resistant guanine nucleotide exchange factor 1; Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity) | 0.459 |
ARFGAP2 | GOSR2 | ENSP00000434442 | ENSP00000225567 | ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network | 0.767 |
ARFGAP2 | MON2 | ENSP00000434442 | ENSP00000377252 | ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | MON2 homolog (S. cerevisiae); May be required for traffic between late Golgi and early endosomes (By similarity) | 0.478 |
ARFGAP3 | ARL5C | ENSP00000263245 | ENSP00000269586 | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | ADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) | 0.615 |
ARFGAP3 | ENSG00000262633 | ENSP00000263245 | ENSP00000461460 | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | Golgi SNAP receptor complex member 2; Uncharacterized protein | 0.772 |
ARFGAP3 | GBF1 | ENSP00000263245 | ENSP00000359000 | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | golgi brefeldin A resistant guanine nucleotide exchange factor 1; Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity) | 0.460 |
ARFGAP3 | GOSR2 | ENSP00000263245 | ENSP00000225567 | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network | 0.775 |
ARFGAP3 | MON2 | ENSP00000263245 | ENSP00000377252 | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | MON2 homolog (S. cerevisiae); May be required for traffic between late Golgi and early endosomes (By similarity) | 0.478 |
ARL5C | ACLY | ENSP00000269586 | ENSP00000253792 | ADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.621 |
ARL5C | ARFGAP2 | ENSP00000269586 | ENSP00000434442 | ADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) | ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | 0.615 |
ARL5C | ARFGAP3 | ENSP00000269586 | ENSP00000263245 | ADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | 0.615 |
ARL5C | ENSG00000262633 | ENSP00000269586 | ENSP00000461460 | ADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) | Golgi SNAP receptor complex member 2; Uncharacterized protein | 0.626 |
ARL5C | ENSG00000267261 | ENSP00000269586 | ENSP00000468367 | ADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) | Ras-related protein Rab-5C | 0.580 |
ARL5C | GBF1 | ENSP00000269586 | ENSP00000359000 | ADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) | golgi brefeldin A resistant guanine nucleotide exchange factor 1; Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity) | 0.642 |
ARL5C | GOSR2 | ENSP00000269586 | ENSP00000225567 | ADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) | golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network | 0.626 |
ARL5C | MON2 | ENSP00000269586 | ENSP00000377252 | ADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) | MON2 homolog (S. cerevisiae); May be required for traffic between late Golgi and early endosomes (By similarity) | 0.566 |
ARL5C | RAB40B | ENSP00000269586 | ENSP00000461785 | ADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) | RAB40B, member RAS oncogene family; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) | 0.568 |