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ENSG00000267261 ENSG00000267261 ARFGAP2 ARFGAP2 MON2 MON2 RAB40B RAB40B ARL5C ARL5C ENSG00000262633 ENSG00000262633 GBF1 GBF1 ARFGAP3 ARFGAP3 GOSR2 GOSR2 ACLY ACLY RAB6A RAB6A
"ARL5C" - ADP-ribosylation factor-like 5C in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARL5CADP-ribosylation factor-like 5C; Binds and exchanges GTP and GDP (By similarity) (179 aa)    
Predicted Functional Partners:
GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1; Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity) (1859 aa)
        score_image   score_image   0.642
ENSG00000262633
Golgi SNAP receptor complex member 2; Uncharacterized protein (232 aa)
        score_image   score_image   0.626
GOSR2
golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network (213 aa)
        score_image   score_image   0.626
ACLY
ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
      score_image score_image   score_image   0.621
ARFGAP2
ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (521 aa)
        score_image   score_image   0.615
ARFGAP3
ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (516 aa)
        score_image   score_image   0.615
ENSG00000267261
Ras-related protein Rab-5C (282 aa)
        score_image   score_image   0.580
RAB6A
RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity (208 aa)
        score_image   score_image   0.570
RAB40B
RAB40B, member RAS oncogene family; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (278 aa)
        score_image   score_image   0.568
MON2
MON2 homolog (S. cerevisiae); May be required for traffic between late Golgi and early endosomes (By similarity) (1717 aa)
        score_image   score_image   0.566
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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