PGPEP1 protein (Homo sapiens) - STRING network view

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PGPEP1

pyroglutamyl-peptidase I; Removes 5-oxoproline from various penultimate amino acid residues except L-proline (209 aa)

Predicted Functional Partners:

PREP

0.816

LAP3

0.759

TRHDE

0.754

TRH

0.750

GTPBP6

0.675

GRP

0.661

NTS

0.603

LSM4

0.545

SSBP4

0.524

LRRTM1

0.508

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRP	LSM4	ENSP00000256857	ENSP00000469468	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA	0.999
GRP	NTS	ENSP00000256857	ENSP00000256010	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle	0.986
GRP	PGPEP1	ENSP00000256857	ENSP00000269919	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	pyroglutamyl-peptidase I; Removes 5-oxoproline from various penultimate amino acid residues except L-proline	0.661
GRP	PREP	ENSP00000256857	ENSP00000358106	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	prolyl endopeptidase; Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long	0.489
GRP	TRH	ENSP00000256857	ENSP00000303452	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes	0.969
GTPBP6	PGPEP1	ENSP00000316598	ENSP00000269919	GTP binding protein 6 (putative)	pyroglutamyl-peptidase I; Removes 5-oxoproline from various penultimate amino acid residues except L-proline	0.675
LAP3	NTS	ENSP00000226299	ENSP00000256010	leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle	0.581
LAP3	PGPEP1	ENSP00000226299	ENSP00000269919	leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pyroglutamyl-peptidase I; Removes 5-oxoproline from various penultimate amino acid residues except L-proline	0.759
LAP3	PREP	ENSP00000226299	ENSP00000358106	leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	prolyl endopeptidase; Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long	0.788
LAP3	TRHDE	ENSP00000226299	ENSP00000261180	leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	thyrotropin-releasing hormone degrading enzyme; Specific inactivation of TRH after its release	0.658
LRRTM1	PGPEP1	ENSP00000295057	ENSP00000269919	leucine rich repeat transmembrane neuronal 1; Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level (By similarity)	pyroglutamyl-peptidase I; Removes 5-oxoproline from various penultimate amino acid residues except L-proline	0.508
LSM4	GRP	ENSP00000469468	ENSP00000256857	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	0.999
LSM4	PGPEP1	ENSP00000469468	ENSP00000269919	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA	pyroglutamyl-peptidase I; Removes 5-oxoproline from various penultimate amino acid residues except L-proline	0.545
LSM4	SSBP4	ENSP00000469468	ENSP00000270061	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA	single stranded DNA binding protein 4	0.409
NTS	GRP	ENSP00000256010	ENSP00000256857	neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	0.986
NTS	LAP3	ENSP00000256010	ENSP00000226299	neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle	leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	0.581
NTS	PGPEP1	ENSP00000256010	ENSP00000269919	neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle	pyroglutamyl-peptidase I; Removes 5-oxoproline from various penultimate amino acid residues except L-proline	0.603
NTS	PREP	ENSP00000256010	ENSP00000358106	neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle	prolyl endopeptidase; Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long	0.767
NTS	TRH	ENSP00000256010	ENSP00000303452	neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle	thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes	0.971
PGPEP1	GRP	ENSP00000269919	ENSP00000256857	pyroglutamyl-peptidase I; Removes 5-oxoproline from various penultimate amino acid residues except L-proline	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	0.661

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