node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCC | IQSEC2 | ENSP00000389140 | ENSP00000379712 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | IQ motif and Sec7 domain 2 | 0.752 |
DCC | IQSEC3 | ENSP00000389140 | ENSP00000315662 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | 0.752 |
DCC | NEO1 | ENSP00000389140 | ENSP00000261908 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | neogenin 1; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues | 0.905 |
DCC | NTN5 | ENSP00000389140 | ENSP00000270235 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | netrin 5 | 0.798 |
FNDC1 | IQSEC2 | ENSP00000297267 | ENSP00000379712 | fibronectin type III domain containing 1 | IQ motif and Sec7 domain 2 | 0.691 |
FNDC1 | IQSEC3 | ENSP00000297267 | ENSP00000315662 | fibronectin type III domain containing 1 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | 0.691 |
FNDC1 | NTN5 | ENSP00000297267 | ENSP00000270235 | fibronectin type III domain containing 1 | netrin 5 | 0.798 |
HHIPL2 | NTN5 | ENSP00000342118 | ENSP00000270235 | HHIP-like 2 | netrin 5 | 0.648 |
HHIPL2 | SGSM3 | ENSP00000342118 | ENSP00000248929 | HHIP-like 2 | small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells | 0.614 |
IGDCC3 | IQSEC2 | ENSP00000332773 | ENSP00000379712 | immunoglobulin superfamily, DCC subclass, member 3 | IQ motif and Sec7 domain 2 | 0.752 |
IGDCC3 | IQSEC3 | ENSP00000332773 | ENSP00000315662 | immunoglobulin superfamily, DCC subclass, member 3 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | 0.752 |
IGDCC3 | NTN5 | ENSP00000332773 | ENSP00000270235 | immunoglobulin superfamily, DCC subclass, member 3 | netrin 5 | 0.835 |
IGDCC4 | IQSEC2 | ENSP00000319623 | ENSP00000379712 | immunoglobulin superfamily, DCC subclass, member 4 | IQ motif and Sec7 domain 2 | 0.691 |
IGDCC4 | IQSEC3 | ENSP00000319623 | ENSP00000315662 | immunoglobulin superfamily, DCC subclass, member 4 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | 0.691 |
IGDCC4 | NTN5 | ENSP00000319623 | ENSP00000270235 | immunoglobulin superfamily, DCC subclass, member 4 | netrin 5 | 0.798 |
IQSEC2 | DCC | ENSP00000379712 | ENSP00000389140 | IQ motif and Sec7 domain 2 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | 0.752 |
IQSEC2 | FNDC1 | ENSP00000379712 | ENSP00000297267 | IQ motif and Sec7 domain 2 | fibronectin type III domain containing 1 | 0.691 |
IQSEC2 | IGDCC3 | ENSP00000379712 | ENSP00000332773 | IQ motif and Sec7 domain 2 | immunoglobulin superfamily, DCC subclass, member 3 | 0.752 |
IQSEC2 | IGDCC4 | ENSP00000379712 | ENSP00000319623 | IQ motif and Sec7 domain 2 | immunoglobulin superfamily, DCC subclass, member 4 | 0.691 |
IQSEC2 | NEO1 | ENSP00000379712 | ENSP00000261908 | IQ motif and Sec7 domain 2 | neogenin 1; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues | 0.752 |